ArticleJournal of the American Society of Nephrology : JASN2015
Direct Reversible Kidney Injury in Familial Hemophagocytic Lymphohistiocytosis Type 3.
Article in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Characterizing the Real-World Risks of Kidney Injuries Associated with Chimeric Antigen Receptor T Cell Therapies-Evidence and Safety.Health data science · 2025Article
- Acute kidney injury following CAR-T cell therapy: a nephrologist's perspective.Clinical kidney journal · 2025Review
- Acute kidney injury in critical care: complications of hemophagocytic lymphohistiocytosis.Frontiers in immunology · 2024Review
- Clinical Features of Cytokine Storm Syndrome.Advances in experimental medicine and biology · 2024Review
- Hemophagocytic Lymphohistiocytosis and Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis Possibly Caused by Enterococcus faecalis Infective Endocarditis.Internal medicine (Tokyo, Japan) · 2023Article
- Safety of CAR-T Cell Therapy in Patients With Renal Failure/Acute Kidney Injury: Focused Review.Clinical hematology international · 2023Review
- Review
- Clinical features and prognostic factors of acute kidney injury caused by adult secondary hemophagocytic lymphohistiocytosis.Journal of nephrology · 2022Article
- Histiocytic Glomerulopathy Associated With Hemophagocytic Lymphohistiocytosis.Kidney medicine · 2022Article
- Low total cholesterol predicts early death in children with hemophagocytic lymphohistiocytosis.Frontiers in pediatrics · 2022Article
- Renal involvement as a unique manifestation of hemophagocytic syndrome.Frontiers in medicine · 2022Article
- A young child with fever and unexplained acute kidney injury: Answers.Pediatric nephrology (Berlin, Germany) · 2018Article
- Hemophagocytic lymphohistiocytosis: an update for nephrologists.International urology and nephrology · 2016Review
- 'Bedside assessment' of acute hantavirus infections and their possible classification into the spectrum of haemophagocytic syndromes.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemophagocytic lymphohistiocytosis is a hyperinflammatory disorder resulting from primary or secondary immune dysfunction. AKI is frequent in severe hemophagocytic lymphohistiocytosis and has been attributed to multiorgan failure or the use of nephrotoxic drugs, but AKI is rarely considered a direct consequence of the disease process. We describe a child with familial hemophagocytic lymphohistiocytosis type 3 who developed AKI requiring prolonged renal replacement therapy because of severe renal inflammation. There was massive infiltration of the renal parenchyma by activated macrophages and cytotoxic T cells, and acute tubular injury. The patient responded to high-dose intravenous methylprednisolone, which resulted in improvement of renal function and discontinuation of renal replacement therapy. This case confirms the occurrence of reversible AKI due to hemophagocytic lymphohistiocytosis-induced activated macrophage infiltration of the renal parenchyma and inflammation.
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