ArticleAnnals of neurology2015
Physiological consequences of abnormal connectivity in a developmental epilepsy.
Article in Annals of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Transcranial magnetic stimulation-evoked electroencephalography responses as biomarkers for epilepsy: A review of study design and outcomes.Human brain mapping · 2023Pooled it
- Effects of antiepileptic drugs on cortical excitability in humans: A TMS-EMG and TMS-EEG study.Human brain mapping · 2019Trial
- Lamotrigine and levetiracetam exert a similar modulation of TMS-evoked EEG potentials.Epilepsia · 2017Trial
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Article
- Pre-Stimulus Power but Not Phase Predicts Prefrontal Cortical Excitability in TMS-EEG.Biosensors · 2023Article
- Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Experimental suppression of transcranial magnetic stimulation-electroencephalography sensory potentials.Human brain mapping · 2022Article
- High-Frequency Oscillations and Epileptogenic Network.Current neuropharmacology · 2022Article
- Prefrontal reactivity to TMS perturbation as a toy model of mental health outcomes during the COVID-19 pandemic.Heliyon · 2022Article
- A structured ICA-based process for removing auditory evoked potentials.Scientific reports · 2022Article
- Continuous theta burst stimulation for drug-resistant epilepsy.Frontiers in neuroscience · 2022Article
- TMS-Evoked Prefrontal Perturbation as a Toy Model of Brain Resilience to Stress During the COVID-19 Pandemic.Research square · 2021Article
- Widespread cortical dyslamination in epilepsy patients with malformations of cortical development.Neuroradiology · 2021Article
- Thalamic Local Field Potentials Are Related to Long-Term DBS Effects in Tourette Syndrome.Frontiers in neurology · 2021Article
- Treatment of Epilepsy Associated with Periventricular Nodular Heterotopia.Current neurology and neuroscience reports · 2020Review
- Spatiotemporal Dynamics of Single and Paired Pulse TMS-EEG Responses.Brain topography · 2020Article
- Individualized perturbation of the human connectome reveals reproducible biomarkers of network dynamics relevant to cognition.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Changing concepts in presurgical assessment for epilepsy surgery.Nature reviews. Neurology · 2019Review
- Reading deficits correlate with cortical and subcortical volume changes in a genetic migration disorder.Medicine · 2019Observational
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
Abstract
objectiveMany forms of epilepsy are associated with aberrant neuronal connections, but the relationship between such pathological connectivity and the underlying physiological predisposition to seizures is unclear. We sought to characterize the cortical excitability profile of a developmental form of epilepsy known to have structural and functional connectivity abnormalities.
methodsWe employed transcranial magnetic stimulation (TMS) with simultaneous electroencephalographic (EEG) recording in 8 patients with epilepsy from periventricular nodular heterotopia and matched healthy controls. We used connectivity imaging findings to guide TMS targeting and compared the evoked responses to single-pulse stimulation from different cortical regions.
resultsHeterotopia patients with active epilepsy demonstrated a relatively augmented late cortical response that was greater than that of matched controls. This abnormality was specific to cortical regions with connectivity to subcortical heterotopic gray matter. Topographic mapping of the late response differences showed distributed cortical networks that were not limited to the stimulation site, and source analysis in 1 subject revealed that the generator of abnormal TMS-evoked activity overlapped with the spike and seizure onset zone.
interpretationOur findings indicate that patients with epilepsy from gray matter heterotopia have altered cortical physiology consistent with hyperexcitability, and that this abnormality is specifically linked to the presence of aberrant connectivity. These results support the idea that TMS-EEG could be a useful biomarker in epilepsy in gray matter heterotopia, expand our understanding of circuit mechanisms of epileptogenesis, and have potential implications for therapeutic neuromodulation in similar epileptic conditions associated with deep lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.