ArticleActa biomaterialia2015
Silk scaffolds with tunable mechanical capability for cell differentiation.
Article in Acta biomaterialia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed.
- Mechanical and structural responses of silk fibroin scaffolds to MechanoCulture T6® bioreactor loading and enzymatic degradation.Journal of the mechanical behavior of biomedical materials · 2026Article
- Integrated approach to cell growth and recovery in silk fibroin scaffolds via a spin-down system.Biomaterials and biosystems · 2025Article
- Tissue-engineered liver using 3D-printed silk fibroin scaffolds loaded with stem cells for the treatment of acute liver injury.Regenerative biomaterials · 2025Article
- Biodegradable Silk Fibroin Matrices for Wound Closure in a Human 3D Ex Vivo Approach.Materials (Basel, Switzerland) · 2024Article
- Mechanical strategies to promote vascularization for tissue engineering and regenerative medicine.Burns & trauma · 2024Review
- An overview of substrate stiffness guided cellular response and its applications in tissue regeneration.Bioactive materials · 2022Review
- Silk Fibroin-Based Therapeutics for Impaired Wound Healing.Pharmaceutics · 2022Review
- Nerve Guidance Conduits with Hierarchical Anisotropic Architecture for Peripheral Nerve Regeneration.Advanced healthcare materials · 2021Article
- Structure of Silk I (Molecules (Basel, Switzerland) · 2021Review
- Article
- Recombinant Silk Fibroin Crystalline Regions as Biomaterial Alternatives to the Full-Length Protein.ACS biomaterials science & engineering · 2020Article
- Self-Folding 3D Silk Biomaterial Rolls to Facilitate Axon and Bone Regeneration.Advanced healthcare materials · 2020Article
- Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration.Biomaterials science · 2020Article
- The Mechanical Properties, Secondary Structure, and Osteogenic Activity of Photopolymerized Fibroin.Polymers · 2020Article
- Can Keratin Scaffolds be used for Creating Three-dimensional Cell Cultures?Open medicine (Warsaw, Poland) · 2020Article
- Mechanistic insights into silk fibroin's adhesive properties via chemical functionalization of serine side chains.ACS biomaterials science & engineering · 2019Article
- Bioactive Silk Hydrogels with Tunable Mechanical Properties.Journal of materials chemistry. B · 2018Article
- Materials-Directed Differentiation of Mesenchymal Stem Cells for Tissue Engineering and Regeneration.ACS biomaterials science & engineering · 2018Article
- Biological effects of silk fibroin 3D scaffolds on stem cells from human exfoliated deciduous teeth (SHEDs).Odontology · 2018Article
- Simulation of ECM with Silk and Chitosan Nanocomposite Materials.Journal of materials chemistry. B · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Bombyx mori silk fibroin is a promising biomaterial for tissue regeneration and is usually considered an "inert" material with respect to actively regulating cell differentiation due to few specific cell signaling peptide domains in the primary sequence and the generally stiffer mechanical properties due to crystalline content formed in processing. In the present study, silk fibroin porous 3D scaffolds with nanostructures and tunable stiffness were generated via a silk fibroin nanofiber-assisted lyophilization process. The silk fibroin nanofibers with high β-sheet content were added into the silk fibroin solutions to modulate the self-assembly, and to directly induce water-insoluble scaffold formation after lyophilization. Unlike previously reported silk fibroin scaffold formation processes, these new scaffolds had lower overall β-sheet content and softer mechanical properties for improved cell compatibility. The scaffold stiffness could be further tuned to match soft tissue mechanical properties, which resulted in different differentiation outcomes with rat bone marrow-derived mesenchymal stem cells toward myogenic and endothelial cells, respectively. Therefore, these silk fibroin scaffolds regulate cell differentiation outcomes due to their mechanical features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.