ArticleJournal of hepatology2015
Early post-transplant survival: Interaction of MELD score and hospitalization status.
Article in Journal of hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Preoperative nutritional scores to predict mortality after liver transplantation: a retrospective cohort study.Anesthesia and pain medicine · 2024Article
- A decline in functional status while awaiting liver transplantation is predictive of increased post-transplantation mortality.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2022Article
- Textbook Outcome as a Quality Metric in Liver Transplantation.Transplantation direct · 2022Article
- Con: Patients With Acute-on-Chronic Liver Failure Should Not Receive Priority on the Waiting List.Clinical liver disease · 2022Review
- Women who undergo liver transplant have longer length of stay post-transplant compared with men.Liver international : official journal of the International Association for the Study of the Liver · 2020Article
- Transplantation for Acute-on-Chronic Liver Failure.Clinical liver disease · 2019Review
- Pre-Operative Delta-MELD is an Independent Predictor of Higher Mortality following Liver Transplantation.Scientific reports · 2019Article
- Approaches for patients with very high MELD scores.JHEP reports : innovation in hepatology · 2019Review
- Plasma levels of soluble ST2, but not IL-33, correlate with the severity of alcoholic liver disease.Journal of cellular and molecular medicine · 2019Article
- Liver transplantation for critically ill cirrhotic patients: Overview and pragmatic proposals.World journal of gastroenterology · 2018Review
- Healthcare utilization after liver transplantation is highly variable among both centers and recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Article
- A novel learning algorithm to predict individual survival after liver transplantation for primary sclerosing cholangitis.PloS one · 2018Article
- Prognosis of cirrhotic patients admitted to intensive care unit: a meta-analysis.Annals of intensive care · 2017Article
- Significance of Proper Graft Selection in Adult Living-Donor Liver Transplant Recipients with Preoperative Deteriorated Condition.Annals of transplantation · 2017Article
- Improving outcomes for transplantation of critically ill patients with cirrhosis?Clinical liver disease · 2017Review
- Predicting short-term survival after liver transplantation on eight score systems: a national report from China Liver Transplant Registry.Scientific reports · 2017Article
- Single-Center Experience on Liver Transplantation for Model for End-Stage Liver Disease Score 40 Patients.Digestive diseases and sciences · 2016Article
- End-stage liver disease patients with MELD >40 have higher waitlist mortality compared to Status 1A patients.Hepatology international · 2016Article
- Pretransplant Factors and Associations with Postoperative Respiratory Failure, ICU Length of Stay, and Short-Term Survival after Liver Transplantation in a High MELD Population.Journal of transplantation · 2016Article
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3 authors.
Funding
Abstract
BACKGROUND &
aimsUrgency-based allocation that relies on the MELD score prioritizes patients at the highest risk of waitlist mortality. However, identifying patients at greatest risk for short-term post-transplant mortality is needed in order to optimize the potential gains in overall survival obtained through improved long-term management of transplant recipients. There are limited data on the predictive ability of MELD score for early post-transplant mortality, and no data assessing the interaction between MELD score and hospitalization status.
methodsWe analyzed UNOS data from 2002 to 2013 on 50,838 non-status 1 single-organ liver transplant recipients and fit multivariable logistic models to evaluate the association and interaction between MELD score and pre-transplant hospitalization status on short-term post-transplant mortality.
resultsThere was a significant interaction (p<0.01) between laboratory MELD score and hospitalization status on three-, six-, and 12-month post-transplant mortality in multivariable logistic models. This interaction was most pronounced in patients with a laboratory MELD score <25 transplanted from an ICU, whose adjusted predicted three-, six-, and 12-month post-transplant mortality approximated those of patients with a MELD score ⩾30. Compared to hospitalized patients with a MELD score of 30-34, those with a MELD score ⩾35 in an ICU had significantly increased risk of three-month (OR: 1.54, 95% CI: 1.21-1.97), 6-month (OR: 1.35, 95% CI: 1.09-1.67), and 12-month (OR: 1.25, 95% CI: 1.03-1.52) post-transplant mortality. DISCUSSION: Pre-transplant ICU status modifies the risk of early post-transplant mortality, independent of MELD score. This should be considered when determining candidacy for transplantation in order to optimize efficient use of a scarce resource.
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