ArticleAnnals of clinical microbiology and antimicrobials2015
Extremely high prevalence of antiseptic resistant Quaternary Ammonium Compound E gene among clinical isolates of multiple drug resistant Acinetobacter baumannii in Malaysia.
Article in Annals of clinical microbiology and antimicrobials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 60 citations in OpenAlex.
- Draft genome sequence of an Acinetobacter albensis strain from untreated wastewater.Access microbiology · 2026Article
- Emerging Challenges: High frequency of Antiseptic Resistance Encoding Genes and Reduced Biguanide Susceptibility in Antibiotic-ResistantArchives of Razi Institute · 2025Article
- The Slow Pandemic: Emergence of Antimicrobial Resistance in the Postadvent of SARS-CoV-2 Pandemic.Global health, epidemiology and genomics · 2025Review
- Imidazoles and Quaternary Ammonium Compounds as Effective Therapies against (Multidrug-Resistant) Bacterial Wound Infections.Antibiotics (Basel, Switzerland) · 2024Article
- Molecular distribution of biocide resistance genes and susceptibility to biocides among vancomycin resistantHeliyon · 2023Article
- Molecular Epidemiological Investigation and Management of Outbreak Caused by Carbapenem-ResistantMicroorganisms · 2023Article
- Genotyping ofAccess microbiology · 2023Article
- Phenotype and genetic determination of resistance to common disinfectants among biofilm-producing and non-producing Pseudomonas aeruginosa strains from clinical specimens in Iran.BMC microbiology · 2022Article
- Evaluating the Effectiveness of Hospital Antiseptics on Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Upregulation ofHealth science reports · 2021Article
- Antibacterial effects of Octenicept, and benzalkonium chloride on Acinetobacter baumannii strains isolated from clinical samples and determination of genetic diversity of isolates by RAPD-PCR method.Molecular biology reports · 2021Article
- Biological activity of quaternary ammonium salts and resistance of microorganisms to these compounds.World journal of microbiology & biotechnology · 2021Review
- Peptide-Based Efflux Pump Inhibitors of the Small Multidrug Resistance Protein from Pseudomonas aeruginosa.Antimicrobial agents and chemotherapy · 2019Article
- Acinetobacter baumannii - a neglected pathogen in veterinary and environmental health in Germany.Veterinary research communications · 2019Review
- Comparative genomic analysis and multi-drug resistance differences ofInfection and drug resistance · 2019Article
- High Prevalence of blaMicroorganisms · 2017Article
- Molecular Characterization of Reduced Susceptibility to Biocides in Clinical Isolates ofFrontiers in microbiology · 2017Article
- Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?GMS hygiene and infection control · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntiseptics are commonly used for the management of MDR (multiple drug resistance) pathogens in hospitals. They play crucial roles in the infection control practices. Antiseptics are often used for skin antisepsis, gauze dressing, preparation of anatomical sites for surgical procedure, hand sterilization before in contact with an infected person, before an invasive procedure and as surgical scrub.
methodsWe screened 122 multiple drug resistant Acinetobacter baumannii (MDRAB) isolated from admitted patients in one of the tertiary care hospital in Malaysia for the presence of antiseptic resistant genes qacA and qacE (Quaternary Ammonium Compound) and susceptibility towards chlorhexidine (CLX), benzalkonium (BZK) and benzethonium (BZT).
resultsEighty-nine (73%) isolates harboured qacE gene, while none were positive for qacA. The MIC ranged from 0.2 to 0.6 for CLX, 0.02 to 0.2 for BZK and 0.04 to 0.2 μg/mL for BZT. The highest number of qacE positive isolates were obtained from surgery (n = 24; 27%; p < 0.05), followed by medical ward (n = 23; 25.8%) and ICU (n = 21; 23.6%). Majority of the isolates from wound swabs (n = 33; 37%), T/aspirate (n = 16; 18%) and tissue (n = 10; 11.2%) harboured the qacE genes.
conclusionThe present investigation showed high prevalence of qacE gene among the studied isolates. Antiseptics are important components of infection control, continuous monitoring of antiseptics use in the hospital is cautioned.
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