Trial reportBMC medicine2015
The Brief Memory and Executive Test (BMET) for detecting vascular cognitive impairment in small vessel disease: a validation study.
Trial report in BMC medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Pooled it
- Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- The effect of phosphodiesterase-5 inhibitors on cerebral blood flow in humans: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Pooled it
- Metabolic Markers of MRI-Confirmed Lacunar Stroke: Observational and Mendelian Randomization Analyses.Neurology · 2026Observational
- An Investigation of the Psychometric Properties of the Farsi Version of the Saint Louis University Mental Status Examination.Dementia and geriatric cognitive disorders · 2026Article
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- Psychometric assessment of the translated and culturally adapted Chinese (Cantonese) of the brief memory and executive test in people with stroke.European journal of physical and rehabilitation medicine · 2025Article
- Prevalence of Fatigue and Associations With Depression and Cognitive Impairment in Patients With CADASIL.Neurology · 2025Article
- Rethinking neuropsychological test validity in dementia assessment: a critical review in the age of neuroimaging and digital markers.Frontiers in human neuroscience · 2025Review
- Improvement of an External Predictive Model Based on New Information Using a Synthetic Data Approach: Application to CADASIL.Neurology. Genetics · 2023Article
- New horizons in cognitive and functional impairment as a consequence of cerebral small vessel disease.Age and ageing · 2023Article
- Prevalence of, and risk factors for, cognitive impairment in lacunar stroke.International journal of stroke : official journal of the International Stroke Society · 2023Article
- Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review.JAMA neurology · 2022Review
- Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- The montreal cognitive assessment and mini-mental state examination visuoexecutive subtests in acute ischemic stroke patients and their correlations with demographic and clinical factors.Acta neurologica Belgica · 2021Article
- A Virtual Reality-Based Screening Test for Cognitive Impairment in Small Vessel Disease.Journal of Alzheimer's disease reports · 2021Article
- The SNP43 (G/A) polymorphism in CAPN10 gene confers an increased risk of cognitive impairment in cerebral small vessel disease.Journal of clinical laboratory analysis · 2018Article
- Update on Vascular Cognitive Impairment Associated with Subcortical Small-Vessel Disease.Journal of Alzheimer's disease : JAD · 2018Review
- MRI Lesion Load of Cerebral Small Vessel Disease and Cognitive Impairment in Patients With CADASIL.Frontiers in neurology · 2018Article
- Mnemonic function in small vessel disease and associations with white matter tract microstructure.Neuropsychologia · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundCognitive impairment is common in patients with cerebral small vessel disease, but is not well detected using common cognitive screening tests which have been primarily devised for cortical dementias. We developed the Brief Memory and Executive Test (BMET); a rapid screening measure sensitive to the impaired executive function and processing speed characteristic of small vessel disease (SVD). To assess the BMET's validity for general use, we evaluated it when administered by non-psychologists in a multicentre study and collected control data to derive normative scores.
methodsTwo-hundred participants with SVD, defined as a clinical lacunar stroke and a corresponding lacunar infarct on MRI, and 303 healthy controls aged between 40-90 years old were recruited. The BMET, as well as the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE), were performed. Overall, 55 SVD participants underwent repeat testing at 3 months to assess the BMET test-retest reliability.
resultsAdministering the BMET took a mean (SD) of 12.9 (4.7) in cases and 9.5 (2.6) minutes in controls. Receiver Operator Curve analysis showed the BMET was a good predictor of cognitive impairment in SVD (AUC = 0.94) and performed significantly better than both the MoCA (AUC = 0.77) and the MMSE (AUC = 0.70). Using a cut-off score of 13, the BMET had a sensitivity of 93% and specificity of 76% for detecting cognitive impairment in SVD.
conclusionsThe BMET is a brief and sensitive tool for the detection of cognitive impairment in patients with SVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.