ArticleBiochemical and biophysical research communications2015
Molecular imaging of inflammation in the ApoE -/- mouse model of atherosclerosis with IodoDPA.
Article in Biochemical and biophysical research communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
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- Radiotracers for Imaging of Inflammatory Biomarkers TSPO and COX-2 in the Brain and in the Periphery.International journal of molecular sciences · 2023Review
- Theranostic nanoplatform to target macrophages enables the inhibition of atherosclerosis progression and fluorescence imaging of plaque in ApoE(-/-) mice.Journal of nanobiotechnology · 2021Article
- Label-free photoacoustic and ultrasound imaging for murine atherosclerosis characterization.APL bioengineering · 2020Article
- Review
- Imaging and Characterization of Macrophage Distribution in Mouse Models of Human Prostate Cancer.Molecular imaging and biology · 2019Article
- Changing landscape of optical imaging in skeletal metastases.Journal of bone oncology · 2019Review
- Imaging Pulmonary Foreign Body Reaction Using [Molecular imaging and biology · 2019Article
- Biodistribution and Radiation Dosimetry ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Article
- Imaging Macrophage-associated Inflammation.Seminars in nuclear medicine · 2018Review
- In vivo imaging of inflammation and oxidative stress in a nonhuman primate model of cardiac sympathetic neurodegeneration.NPJ Parkinson's disease · 2018Article
- Positron Emission Tomography Imaging of Macrophages in Atherosclerosis withContrast media & molecular imaging · 2018Article
- Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017Article
- Recent Advances in the Development of PET/SPECT Probes for Atherosclerosis Imaging.Nuclear medicine and molecular imaging · 2016Review
- Molecular Imaging of Vulnerable Atherosclerotic Plaques in Animal Models.International journal of molecular sciences · 2016Review
- Molecular Imaging of Inflammation: Current Status.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016Review
- Cardiovascular Imaging in Mice.Current protocols in mouse biology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAtherosclerosis is a common and serious vascular disease predisposing individuals to myocardial infarction and stroke. Intravascular plaques, the pathologic lesions of atherosclerosis, are largely composed of cholesterol-laden luminal macrophage-rich infiltrates within a fibrous cap. The ability to detect those macrophages non-invasively within the aorta, carotid artery and other vessels would allow physicians to determine plaque burden, aiding management of patients with atherosclerosis. METHODS AND
resultsWe previously developed a low-molecular-weight imaging agent, [(125)I]iodo-DPA-713 (iodoDPA), which selectively targets macrophages. Here we use it to detect both intravascular macrophages and macrophage infiltrates within the myocardium in the ApoE -/- mouse model of atherosclerosis using single photon emission computed tomography (SPECT). SPECT data were confirmed by echocardiography, near-infrared fluorescence imaging and histology. SPECT images showed focal uptake of radiotracer at the aortic root in all ApoE -/- mice, while the age-matched controls were nearly devoid of radiotracer uptake. Focal radiotracer uptake along the descending aorta and within the myocardium was also observed in affected animals.
conclusionsIodoDPA is a promising new imaging agent for atherosclerosis, with specificity for the macrophage component of the lesions involved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.