Evidence map›Paper›PMID 25858272›Full record

ReviewVirus research2015

Cis- and trans-regulation of luteovirus gene expression by the 3' end of the viral genome.

W Allen Miller, Jacquelyn Jackson, Ying Feng

Open access · greenAbstract readReview
In one paragraph

Review in Virus research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

  1. Ribosome Profiling of Plants.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  2. Article
  3. Article
  4. Review
  5. Journal of virology · 2021
    Article
  6. Tissue-specific dynamic codon redefinition inProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. A Stem-Loop Structure inJournal of virology · 2018
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

W Allen MillerPlant Pathology & Microbiology Department, Iowa State University, Ames, IA 50011, United States; Interdepartmental Genetics & Genomics Program, Iowa State University, Ames, IA 50011, United States; Bioinformatics & Computational Biology Program, Iowa State University, Ames, IA 50011, United States. Electronic address: wamiller@iastate.edu.
Jacquelyn JacksonPlant Pathology & Microbiology Department, Iowa State University, Ames, IA 50011, United States; Interdepartmental Genetics & Genomics Program, Iowa State University, Ames, IA 50011, United States.
Ying FengPlant Pathology & Microbiology Department, Iowa State University, Ames, IA 50011, United States; Bioinformatics & Computational Biology Program, Iowa State University, Ames, IA 50011, United States.
Iowa State University · US

Funding

Control of cap-independent translation by a viral 3' UTRR01GM067104 · NIGMS · IOWA STATE UNIVERSITY · PI MILLER, WYATT ALLEN · 2003 to 2016
$3.0M
Control of cap-independent translation by a viral 3' UTRR56GM067104 · NIGMS · IOWA STATE UNIVERSITY · PI MILLER, WYATT ALLEN · 2007 to 2007
$227k
Mapping the sgRNA2 and sgRNA3 Promoters of BYDVF31AI056673 · NIAID · IOWA STATE UNIVERSITY · PI JACKSON, JACQUELYN R · 2003 to 2005
$88k
NIAID NIH HHS F31 AI056673NIAID NIH HHS F31 AI 56673NIGMS NIH HHS R01 GM067104NIGMS NIH HHS R56 GM067104PHS HHS 5 R01067104-11
6 · The paper itself

Abstract

Translation of the 5.7 kb luteovirus genome is controlled by the 3' untranslated region (UTR). Base pairing between regions of the 3' UTR and sequences kilobases upstream is required for cap-independent translation and ribosomal frameshifting needed to synthesize the viral replicase. Luteoviruses produce subgenomic RNAs, which can serve as mRNA, but one sgRNA also regulates translation initiation in trans. As on all viruses, the 3' and 5' ends contain structures that are presumed to facilitate RNA synthesis. This review describes the structures and interactions of barley yellow dwarf virus RNA that facilitate the complex interplay between the above events and result in a successful virus infection. We also present surprising results on the apparent lack of need for some subgenomic RNAs for the virus to infect cells or whole plants. In summary, the UTRs of luteoviruses are highly complex entities that control and fine-tune many key events of the virus replication cycle.

Indexed as

3' Untranslated RegionsGene Expression Regulation, ViralGenome, ViralLuteovirusModels, BiologicalModels, MolecularNucleic Acid ConformationProtein BiosynthesisRNA FoldingRNA, Viral3' Untranslated RegionsRNA, ViralBarley yellow dwarf virusCap-independent translationLong-distance base pairingRiboregulatorRNA spongeSubgenomic RNA

Identifiers

PMID25858272
PMCPMC4722956
OpenAlexW2077516286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.