ArticleJournal of child psychology and psychiatry, and allied disciplines2015
The Philadelphia Neurodevelopmental Cohort: constructing a deep phenotyping collaborative.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 5 of them syntheses that pooled it.
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Who cites it
170 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A Developmentally Informed Systematic Review and Meta-Analysis of the Strength of General Psychopathology in Childhood and Adolescence.Clinical child and family psychology review · 2024Pooled it
- Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.Nature medicine · 2023Pooled it
- Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.Nature genetics · 2023Pooled it
- Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder.Translational psychiatry · 2021Pooled it
- Developmental Differences Between Schizophrenia and Bipolar Disorder.Schizophrenia bulletin · 2017Pooled it
- Cannabis use and glutamate across the psychosis spectrum: in vivo evidence from 7T proton magnetic resonance spectroscopy.Molecular psychiatry · 2026Article
- To Collapse or not to Collapse Multiple Measures of the Same Psychological Construct: A Demonstration Across 14 Independent Studies of Autistic and Non-Autistic Children.Research on child and adolescent psychopathology · 2026Article
- Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Preservation of Higher-Order Cognition in Autistic Females: Evidence from Two Deeply-Phenotyped Cohorts in Hong Kong and the United States.Research square · 2026Article
- Sex Differences in Psychopathology and Neurocognition in Community Youth With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- Gene × sex interactions on cognition in the Philadelphia neurodevelopmental cohort.Biology of sex differences · 2026Article
- Genetic Risk and Resilience for Schizophrenia Stratified by Perinatal Gene Expression Predict Adult Cognitive Performance.bioRxiv : the preprint server for biology · 2026Article
- The PMADS Project: A Longitudinal Multimodal Cohort Study to Understand Risk for Perinatal Mood and Anxiety Disorders.bioRxiv : the preprint server for biology · 2026Article
- A Computerized Adaptive Test for the Knowledge of Effective Parenting Test-Internalizing Module: Instrument Validation Study.JMIR formative research · 2026Article
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- An open, fully-processed data resource for studying mood and sleep variability in the developing brain.Aperture neuro · 2026Article
- Do Common Genetic Factors Underlie Comorbidity Between Migraine and Major Depressive Disorder in Youth?Pediatric neurology · 2025Article
- Improved Estimation of Correlation Accuracy for Machine Learning Brain-Phenotype Associations.bioRxiv : the preprint server for biology · 2025Article
- Salience network segregation and symptom profiles in psychosis risk subgroups among youth and early adults.Schizophrenia (Heidelberg, Germany) · 2025Article
- Genetic risk and transdiagnostic traits in anorexia nervosa, obsessive-compulsive disorder, and schizophrenia.Psychological medicine · 2025Article
110 more citing papers are in PubMed but not listed here.
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17 authors.
Funding
Abstract
backgroundAn integrative multidisciplinary approach is required to elucidate the multiple factors that shape neurodevelopmental trajectories of mental disorders. The Philadelphia Neurodevelopmental Cohort (PNC), funded by the National Institute of Mental Health Grand Opportunity (GO) mechanism of the American Recovery and Reinvestment Act, was designed to characterize clinical and neurobehavioral phenotypes of genotyped youths. Data generated, which are recently available through the NIMH Database of Genotypes and Phenotypes (dbGaP), have garnered considerable interest. We provide an overview of PNC recruitment and clinical assessment methods to allow informed use and interpretation of the PNC resource by the scientific community. We also evaluate the structure of the assessment tools and their criterion validity.
methodsParticipants were recruited from a large pool of youths (n = 13,958) previously identified and genotyped at The Children's Hospital of Philadelphia. A comprehensive computerized tool for structured evaluation of psychopathology domains (GOASSESS) was constructed. We administered GOASSESS to all participants and used factor analysis to evaluate its structure.
resultsA total of 9,498 youths (aged 8-21; mean age = 14.2; European American = 55.8%; African American = 32.9%; Other = 11.4%) were enrolled. Factor analysis revealed a strong general psychopathology factor, and specific 'anxious-misery', 'fear', and 'behavior' factors. The 'behavior' factor had a small negative correlation (-0.21) with overall accuracy of neurocognitive performance, particularly in tests of executive and complex reasoning. Being female had a high association with the 'anxious-misery' and low association with the 'behavior' factors. The psychosis spectrum was also best characterized by a general factor and three specific factors: ideas about 'special abilities/persecution,' 'unusual thoughts/perceptions', and 'negative/disorganized' symptoms.
conclusionsThe PNC assessment mechanism yielded psychopathology data with strong factorial validity in a large diverse community cohort of genotyped youths. Factor scores should be useful for dimensional integration with other modalities (neuroimaging, genomics). Thus, PNC public domain resources can advance understanding of complex inter-relationships among genes, cognition, brain, and behavior involved in neurodevelopment of common mental disorders.
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