Evidence map›Paper›PMID 25858196›Full record

ArticleCirculation2015

Adverse childhood experiences and blood pressure trajectories from childhood to young adulthood: the Georgia stress and Heart study.

Shaoyong Su, Xiaoling Wang, Jennifer S Pollock, Frank A Treiber, Xiaojing Xu, Harold Snieder, W Vaughn McCall, Michael Stefanek, Gregory A Harshfield

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05731557 (ACE, Resilience, and Substance Use Disorder), which is not on this map. Cited by 134 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 5 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05731557 completednot on this mapstarted 2020, after this paper: background citation

ACE, Resilience, and Substance Use Disorder: Maternal and Baby Outcomes in the First Year of Life

TypeobservationalSponsorThe Cooper Health SystemRan2020 to 2024Enrolled120ConditionsAdverse Childhood Experiences
3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 5 syntheses or guidelines pooled it, 219 citations in OpenAlex.

  1. Pooled it
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  6. Mindfulness for heart and mind: Mindfulness-based blood pressure reduction randomized clinical trial for depression symptoms.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
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  11. Early life stress blunts time-of-day-specific autonomic function in adult male mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
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74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shaoyong SuFrom Georgia Prevention Institute, Medical College of Georgia (S.S., X.W., X.X., G.A.H.), Department of Psychiatry and Health Behavior (W.V.M.), and Department of Psychological Sciences, College of Science and Mathematics (M.S.), Georgia Regents University, Augusta; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham (J.S.P.); Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.); and Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands (H.S.). ssu@gru.edu.
Xiaoling WangFrom Georgia Prevention Institute, Medical College of Georgia (S.S., X.W., X.X., G.A.H.), Department of Psychiatry and Health Behavior (W.V.M.), and Department of Psychological Sciences, College of Science and Mathematics (M.S.), Georgia Regents University, Augusta; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham (J.S.P.); Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.); and Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands (H.S.).
Jennifer S PollockFrom Georgia Prevention Institute, Medical College of Georgia (S.S., X.W., X.X., G.A.H.), Department of Psychiatry and Health Behavior (W.V.M.), and Department of Psychological Sciences, College of Science and Mathematics (M.S.), Georgia Regents University, Augusta; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham (J.S.P.); Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.); and Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands (H.S.).
Frank A TreiberFrom Georgia Prevention Institute, Medical College of Georgia (S.S., X.W., X.X., G.A.H.), Department of Psychiatry and Health Behavior (W.V.M.), and Department of Psychological Sciences, College of Science and Mathematics (M.S.), Georgia Regents University, Augusta; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham (J.S.P.); Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.); and Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands (H.S.).
Xiaojing XuFrom Georgia Prevention Institute, Medical College of Georgia (S.S., X.W., X.X., G.A.H.), Department of Psychiatry and Health Behavior (W.V.M.), and Department of Psychological Sciences, College of Science and Mathematics (M.S.), Georgia Regents University, Augusta; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham (J.S.P.); Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.); and Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands (H.S.).
Harold SniederFrom Georgia Prevention Institute, Medical College of Georgia (S.S., X.W., X.X., G.A.H.), Department of Psychiatry and Health Behavior (W.V.M.), and Department of Psychological Sciences, College of Science and Mathematics (M.S.), Georgia Regents University, Augusta; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham (J.S.P.); Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.); and Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands (H.S.).
W Vaughn McCallFrom Georgia Prevention Institute, Medical College of Georgia (S.S., X.W., X.X., G.A.H.), Department of Psychiatry and Health Behavior (W.V.M.), and Department of Psychological Sciences, College of Science and Mathematics (M.S.), Georgia Regents University, Augusta; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham (J.S.P.); Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.); and Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands (H.S.).
Michael StefanekFrom Georgia Prevention Institute, Medical College of Georgia (S.S., X.W., X.X., G.A.H.), Department of Psychiatry and Health Behavior (W.V.M.), and Department of Psychological Sciences, College of Science and Mathematics (M.S.), Georgia Regents University, Augusta; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham (J.S.P.); Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.); and Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands (H.S.).
Gregory A HarshfieldFrom Georgia Prevention Institute, Medical College of Georgia (S.S., X.W., X.X., G.A.H.), Department of Psychiatry and Health Behavior (W.V.M.), and Department of Psychological Sciences, College of Science and Mathematics (M.S.), Georgia Regents University, Augusta; Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham (J.S.P.); Technology Applications Center for Healthful Lifestyles, Colleges of Nursing and Medicine, Medical University of South Carolina, Charleston (F.A.T.); and Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands (H.S.).
Technology Applications (United States) · USUniversity of Alabama at Birmingham · USMedical University of South Carolina · US

Funding

Vascular and renal responses to stressP01HL069999 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI GEORGE, VARGHESE · 2002 to 2018
$31.1M
A GENOME-WIDE METHYLATION STUDY ON ESSENTIAL HYPERTENSIONR01HL104125 · NHLBI · AUGUSTA UNIVERSITY · PI WANG, XIAOLING · 2011 to 2015
$2.9M
Epigenetics, a Potential Mechanism Linking Depression to Cardiovascular DiseaseR21HL106333 · NHLBI · AUGUSTA UNIVERSITY · PI SU, SHAOYONG · 2011 to 2012
$425k
NHLBI NIH HHS HL106333-01A1NHLBI NIH HHS P01 HL069999NHLBI NIH HHS P01 HL69999NHLBI NIH HHS R01 HL104125NHLBI NIH HHS R21 HL106333
6 · The paper itself

Abstract

backgroundThe purposes of this study were to assess the long-term effect of adverse childhood experiences (ACEs) on blood pressure (BP) trajectories from childhood to young adulthood and to examine whether this relation is explained by childhood socioeconomic status (SES) or risk behaviors that are associated with ACEs. METHODS AND

resultsSystolic and diastolic BPs were measured up to 16 times (13 times on average) over a 23-year period in 213 African Americans and 181 European Americans 5 to 38 years of age. Retrospective data on traumatic experiences before 18 years of age were collected, including abuse, neglect, and household dysfunction. Individual growth curve modeling within a multilevel framework was used to examine the relation between exposure to ACEs and BP development. No main effect of ACEs on average BP levels was found. However, a significant interaction of ACE score with age(3) was observed (systolic BP, P=0.033; diastolic BP, P=0.017). Subjects who experienced multiple traumatic events during childhood showed a faster rise in BP levels after 30 years of age than those without ACEs. As expected, a graded association of ACEs with childhood socioeconomic status and negative health behaviors was observed (P<0.001). The ACE-systolic BP relation was not explained by these factors, whereas the ACE-diastolic BP relation was partially mediated by illicit drug use.

conclusionIn this novel longitudinal study, we observed that participants who were exposed to multiple ACEs displayed a greater increase in BP levels in young adulthood compared with their counterparts without ACEs.

Indexed as

Blood PressureFamily ConflictAdolescentAdultBlack or African AmericanChildChild AbuseChild, PreschoolFemaleFollow-Up StudiesGeorgiaGrowth DisordersHealth BehaviorHumansHypertensionMaleblood pressureethnic groupslife stresslongitudinal studiesyouth

Identifiers

PMID25858196
PMCPMC4430378
OpenAlexW2117828851

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.