ArticleBrain research bulletin2015
In vivo evidence for neuroplasticity in older adults.
Article in Brain research bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Modulation of long-term potentiation following microdoses of LSD captured by thalamo-cortical modelling in a randomised, controlled trial.BMC neuroscience · 2024Trial
- Radical Imagination: An Afrofuturism and Creative Aging Program for Black Women's Brain Health and Wellness.International journal of environmental research and public health · 2025Article
- Repeated spaced paired-associative stimulation to the parietal-motor pathway maintains corticomotor excitability in older adults.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Personalized brain models link cognitive decline progression to underlying synaptic and connectivity degeneration.Alzheimer's research & therapy · 2025Article
- The interplay between Hebbian and homeostatic plasticity in the adult visual cortex.The Journal of physiology · 2025Article
- Sensory tetanisation to induce long-term-potentiation-like plasticity: A review and reassessment of the approach.The European journal of neuroscience · 2022Review
- Cerebral Blood Flow and Brain Functional Connectivity Changes in Older Adults Participating in a Mindfulness-Based Stress Reduction Program.Behavioral sciences (Basel, Switzerland) · 2022Article
- Age affects temporal response, but not durability, to serial ketamine infusions for treatment refractory depression.Psychopharmacology · 2021Article
- Multimodal Neuroimaging Study of Visual Plasticity in Schizophrenia.Frontiers in psychiatry · 2021Article
- Human Sensory LTP Predicts Memory Performance and Is Modulated by theFrontiers in human neuroscience · 2019Article
- Older Adults Exhibit Greater Visual Cortex Inhibition and Reduced Visual Cortex Plasticity Compared to Younger Adults.Frontiers in neuroscience · 2019Article
- Gene-environment Interactions in Late Life: Linking Psychosocial Stress with Brain Aging.Current neuropharmacology · 2018Review
- Glutamatergic metabolites are associated with visual plasticity in humans.Neuroscience letters · 2017Article
- Increasing Working Memory Load Reduces Processing of Cross-Modal Task-Irrelevant Stimuli Even after Controlling for Task Difficulty and Executive Capacity.Frontiers in human neuroscience · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuroplasticity can be conceptualized as an intrinsic property of the brain that enables modification of function and structure in response to environmental demands. Neuroplastic strengthening of synapses is believed to serve as a critical mechanism underlying learning, memory, and other cognitive functions. Ex vivo work investigating neuroplasticity has been done on hippocampal slices using high frequency stimulation. However, in vivo neuroplasticity in humans has been difficult to demonstrate. Recently, a long-term potentiation-like phenomenon, a form of neuroplastic change, was identified in young adults by differences in visual evoked potentials (VEPs) that were measured before and after tetanic visual stimulation (TVS). The current study investigated whether neuroplastic changes in the visual pathway can persist in older adults. Seventeen healthy subjects, 65 years and older, were recruited from the community. Subjects had a mean age of 77.4 years, mean education of 17 years, mean MMSE of 29.1, and demonstrated normal performance on neuropsychological tests. 1Hz checkerboard stimulation, presented randomly to the right or left visual hemi-field, was followed by 2min of 9Hz stimulation (TVS) to one hemi-field. After 2min of rest, 1Hz stimulation was repeated. Temporospatial principal component analysis was used to identify the N1b component of the VEPs, at lateral occipital locations, in response to 1Hz stimulation pre- and post-TVS. Results showed that the amplitude of factors representing the early and late N1b component was substantially larger after tetanic stimulation. These findings indicate that high frequency visual stimulation can enhance the N1b in cognitively high functioning old adults, suggesting that neuroplastic changes in visual pathways can continue into late life. Future studies are needed to determine the extent to which this marker of neuroplasticity is sustained over a longer period of time, and is influenced by age, cognitive status, and neurodegenerative disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.