ArticleJournal of the American College of Cardiology2015
Mechanisms of bone marrow-derived cell therapy in ischemic cardiomyopathy with left ventricular assist device bridge to transplant.
Article in Journal of the American College of Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Adult Stem Cell Therapy and Heart Failure, 2000 to 2016: A Systematic Review.JAMA cardiology · 2016Pooled it
- DCM Support: cell therapy and circulatory support for dilated cardiomyopathy patients with severe ventricular impairment.ESC heart failure · 2023Article
- Novel Targets for a Combination of Mechanical Unloading with Pharmacotherapy in Advanced Heart Failure.International journal of molecular sciences · 2022Review
- Epicardial Transplantation of Autologous Cardiac Micrografts During Coronary Artery Bypass Surgery.Frontiers in cardiovascular medicine · 2021Article
- Stem Cell Therapy for Chronic and Advanced Heart Failure.Current heart failure reports · 2020Review
- Microencapsulated Insulin-Like Growth Factor-1 therapy improves cardiac function and reduces fibrosis in a porcine acute myocardial infarction model.Scientific reports · 2020Article
- Transplantation of human induced pluripotent stem cell-derived cardiomyocytes improves myocardial function and reverses ventricular remodeling in infarcted rat hearts.Stem cell research & therapy · 2020Article
- Function Follows Form - A Review of Cardiac Cell Therapy.Circulation journal : official journal of the Japanese Circulation Society · 2019Review
- Can stem cell therapy increase the rate of myocardial recovery in left ventricular assist device-supported advanced heart failure patients?-current data and future perspectives.Annals of translational medicine · 2019Article
- Cell-Based Therapy for Myocardial Dysfunction After Fontan Operation in Hypoplastic Left Heart Syndrome.Mayo Clinic proceedings. Innovations, quality & outcomes · 2017Article
- Heterotopic transplantation of a decellularized and recellularized whole porcine heart.Interactive cardiovascular and thoracic surgery · 2016Article
- Allogeneic Precursor Cells for Systolic Heart Failure: A Need for Mechanisms in Humans.Circulation research · 2015Article
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8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundClinical trials report improvements in function and perfusion with direct injection of bone marrow cells into the hearts of patients with ischemic cardiomyopathy. Preclinical data suggest these cells improve vascular density, which would be expected to decrease fibrosis and inflammation.
objectivesThe goal of this study was to test the hypothesis that bone marrow stem cells (CD34+) will improve histological measurements of vascularity, fibrosis, and inflammation in human subjects undergoing left ventricular assist device (LVAD) placement as a bridge to cardiac transplantation.
methodsSubjects with ischemic cardiomyopathy who were scheduled for placement of an LVAD as a bridge to transplantation underwent bone marrow aspiration the day before surgery; the bone marrow was processed into cell fractions (bone marrow mononuclear cells, CD34+, and CD34-). At LVAD implantation, all fractions and a saline control were injected epicardially into predetermined areas and each injection site marked. At the time of transplantation, injected areas were collected. Data were analyzed by paired Student t test comparing the effect of cell fractions injected within each subject.
resultsSix subjects completed the study. There were no statistically significant differences in complications with the procedure versus control subjects. Histological analysis indicated that myocardium injected with CD34+ cells had decreased density of endothelial cells compared to saline-injected myocardium. There were no significant differences in fibrosis or inflammation between groups; however, density of activated fibroblasts was decreased in both CD34+ and CD34- injected areas.
conclusionsTissue analysis does not support the hypothesis that bone marrow-derived CD34+ cells promote increased vascular tissue in humans with ischemic cardiomyopathy via direct injection.
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