ArticleBMC biology2015
Cell lineage branching as a strategy for proliferative control.
Article in BMC biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Cell cycle criticality as a mechanism for robust cell population control.Molecular systems biology · 2026Article
- A damage-structured PDE model of stem cell hierarchies: The dual role of dedifferentiation in tissue homeostasis and aging.PloS one · 2026Article
- The inherent fragility of collective proliferative control.iScience · 2025Article
- Reconstructing axial progenitor field dynamics in mouse stem cell-derived embryoids.Developmental cell · 2024Article
- Article
- Macroscopic quorum sensing sustains differentiating embryonic stem cells.Nature chemical biology · 2023Article
- Voices carry.Nature chemical biology · 2023Article
- Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy.eLife · 2023Article
- Regulatory feedback effects on tissue growth dynamics in a two-stage cell lineage model.Physical review. E · 2021Article
- Roadmap for the multiscale coupling of biochemical and mechanical signals during development.Physical biology · 2021Review
- Optimal experimental design for mathematical models of haematopoiesis.Journal of the Royal Society, Interface · 2021Article
- Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes.eLife · 2020Article
- Modelling stem cell ageing: a multi-compartment continuum approach.Royal Society open science · 2020Article
- Controlling organism size by regulating constituent cell numbers.Proceedings of the ... IEEE Conference on Decision & Control. IEEE Conference on Decision & Control · 2018Article
- Exploring intermediate cell states through the lens of single cells.Current opinion in systems biology · 2018Article
- Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits.Molecular systems biology · 2017Article
- Brain evolution and development: adaptation, allometry and constraint.Proceedings. Biological sciences · 2016Review
- Implementation Considerations, Not Topological Differences, Are the Main Determinants of Noise Suppression Properties in Feedback and Incoherent Feedforward Circuits.PLoS computational biology · 2016Article
- An engineering viewpoint on biological robustness.BMC biology · 2016Review
- Feedback control in planarian stem cell systems.BMC systems biology · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundHow tissue and organ sizes are specified is one of the great unsolved mysteries in biology. Experiments and mathematical modeling implicate feedback control of cell lineage progression, but a broad understanding of what lineage feedback accomplishes is lacking.
resultsBy exploring the possible effects of various biologically relevant disturbances on the dynamic and steady state behaviors of stem cell lineages, we find that the simplest and most frequently studied form of lineage feedback - which we term renewal control - suffers from several serious drawbacks. These reflect fundamental performance limits dictated by universal conservation-type laws, and are independent of parameter choice. Here we show that introducing lineage branches can circumvent all such limitations, permitting effective attenuation of a wide range of perturbations. The type of feedback that achieves such performance - which we term fate control - involves promotion of lineage branching at the expense of both renewal and (primary) differentiation. We discuss the evidence that feedback of just this type occurs in vivo, and plays a role in tissue growth control.
conclusionsRegulated lineage branching is an effective strategy for dealing with disturbances in stem cell systems. The existence of this strategy provides a dynamics-based justification for feedback control of cell fate in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.