Evidence map›Paper›PMID 25857334›Full record

SynthesisMaternal & child nutrition2015

The effect of balanced protein energy supplementation in undernourished pregnant women and child physical growth in low- and middle-income countries: a systematic review and meta-analysis.

Briony Stevens, Petra Buettner, Kerrianne Watt, Alan Clough, Julie Brimblecombe, Jenni Judd

2 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Maternal & child nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 51 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 10 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03668977 nacompletednot on this mapstarted 2018, after this paper: background citation

Impact of a Balanced Protein-Energy Supplement in Pregnancy and Early Lactation on Reproductive Outcomes and Growth in Southern Nepal

TypeinterventionalSponsorGeorge Washington UniversityRan2018 to 2024Enrolled1,944ConditionsPregnancy and Early Lactation Among Women Living in an Area Endemic for MalnutritionArmsFortified balanced protein-energy.
NCT06405360 naterminatednot on this mapstarted 2024, after this paper: background citation

DEUX OEUFs:Cracking the Potential of Eggs to Improve Child Growth and Development

TypeinterventionalSponsorUniversity of FloridaRan2024 to 2026Enrolled464ConditionsInfant Malnutrition, Fetal Growth RetardationArmsEgg consumption
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 10 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Briony StevensSchool of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland, Australia.
Petra BuettnerSchool of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland, Australia.
Kerrianne WattSchool of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland, Australia.
Alan CloughSchool of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland, Australia.
Julie BrimblecombeSchool of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
Jenni JuddSchool of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland, Australia.
Australian Institute of Tropical Health and Medicine · AUJames Cook University · AUMenzies School of Health Research · AUQueensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The beneficial effect of balanced protein energy supplementation during pregnancy on subsequent child growth is unclear and may depend upon the mother entering pregnancy adequately nourished or undernourished. Systematic reviews to-date have included studies from high-, middle- and low-income countries. However, the effect of balanced protein energy supplementation should not be generalised. This review assesses the effect of balanced protein energy supplementation in undernourished pregnant women from low- and middle-income countries on child growth. A systematic review of articles published in English (1970-2015) was conducted via MEDLINE, Scopus, the Cochrane Register and hand searching. Only peer-reviewed experimental studies analysing the effects of balanced protein energy supplementation in undernourished pregnant women from low- and middle-income countries with measures of physical growth as the primary outcome were included. Two reviewers independently assessed full-text articles against inclusion criteria. Validity of eligible studies was ascertained using the Quality Assessment Tool for Quantitative Studies (EPHPP QAT). In total, seven studies met the inclusion criteria. All studies reported on birthweight, five on birth length, three on birth head circumference, and one on longer-term growth. Standardised mean differences were calculated using a random-effects meta-analysis. Balanced protein energy supplementation significantly improved birthweight (seven randomised controlled trials, n = 2367; d = 0.20, 95% confidence interval, 0.03-0.38, P = 0.02). No significant benefit was observed on birth length or birth head circumference. Impact of intervention could not be determined for longer-term physical growth due to limited evidence. Additional research is required in low- and middle-income countries to identify impacts on longer-term infant growth.

Indexed as

Developing CountriesInfant Nutritional Physiological PhenomenaMaternal Nutritional Physiological PhenomenaBirth WeightChild DevelopmentDietary ProteinsDietary SupplementsEnergy IntakeFemaleHumansInfantInfant, NewbornPovertyPregnancyDietary Proteinschild growthinternational child health nutritionlow-income countriesmaternal nutritionsystematic reviewunderweight

Identifiers

PMID25857334
PMCPMC6860195
OpenAlexW1793449521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.