ArticlePloS one2015
Molecular typing and epidemiology profiles of human adenovirus infection among paediatric patients with severe acute respiratory infection in China.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 48 citations in OpenAlex.
- Clinical profile and risk factors of severe adenoviral infections among hospitalised children in South India: a cross-sectional study.BMJ paediatrics open · 2026Article
- Association of human adenovirus load and viral genotype diversity with respiratory disease severity in children: a systematic review and meta-analysis.Translational pediatrics · 2025Article
- Epidemiological characteristics of adenovirus in children in Yancheng, China, 2023-2024.Frontiers in cellular and infection microbiology · 2025Article
- Molecular characterization of human adenoviruses associated with pediatric respiratory infections in Karachi, Pakistan.BMC infectious diseases · 2024Article
- Activation of the NLRP3 inflammasome by human adenovirus type 7 L4 100-kilodalton protein.Frontiers in immunology · 2024Article
- Molecular subtypes of Adenovirus-associated acute respiratory infection outbreak in children in Northern Vietnam and risk factors of more severe cases.PLoS neglected tropical diseases · 2023Article
- Detection of human adenoviruses in influenza-negative patients with respiratory tract infections in Nanning, China.Virology journal · 2023Article
- Article
- Mortality reduction in pediatric patients with severe fatal human adenoviral pneumonia treated with high titer neutralizing antibodies (NAbs) plasma: a retrospective cohort study.BMC pediatrics · 2022Article
- Chinese expert consensus on immunoprophylaxis of common respiratory pathogens in children (2021 edition).Journal of thoracic disease · 2022Review
- Article
- Molecular typing of human adenoviruses among hospitalized patients with respiratory tract infections in a tertiary Hospital in Guangzhou, China between 2017 and 2019.BMC infectious diseases · 2021Article
- Application of Human Adenovirus Genotyping by Phylogenetic Analysis in an Outbreak to Identify Nosocomial Infection.Virologica Sinica · 2021Article
- Human adenovirus species in children with acute respiratory illnesses.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2021Article
- Adenovirus infection in children hospitalized with pneumonia in Guangzhou, China.Influenza and other respiratory viruses · 2021Article
- Outbreak of severe acute respiratory infection in Southern Province, Sri Lanka in 2018: a cross-sectional study.BMJ open · 2020Article
- Whole genomic analysis of a potential recombinant human adenovirus type 1 in Qinghai plateau, China.Virology journal · 2020Article
- Histone Deacetylase Inhibitors Promote Latent Adenovirus Reactivation from Tonsillectomy Specimens.Journal of virology · 2020Article
- Molecular and clinical characterization of human adenovirus associated with acute respiratory tract infection in hospitalized children.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020Article
- Evaluation of Risk Factors for Exacerbations in Children with Adenoviral Pneumonia.BioMed research international · 2020Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman adenoviruses (HAdVs) have been recognised as pathogens that cause a broad spectrum of diseases. The studies on HAdV infection among children with severe acute respiratory infection (SARI) are limited.
objectiveTo investigate the prevalence, epidemiology, and genotype of HAdV among children with SARI in China. STUDY
designNasopharyngeal aspirates (NPAs) or induced sputum (IS) was collected from hospitalised children with SARIs in Beijing (representing Northern China; n = 259) and Zhejiang Province (representing Eastern China; n = 293) from 2007 to 2010. The prevalence of HAdV was screened by polymerase chain reaction (PCR), followed by sequence typing of PCR fragments that targeted the second half of the hexon gene. In addition, co-infection with other human respiratory viruses, related epidemiological profiles and clinical presentations were investigated. RESULTS AND
conclusionsIn total, 76 (13.8%) of 552 SARI patients were positive for HAdV, and the infection rates of HAdV in Northern and Eastern China were 20.1% (n = 52) and 8.2% (n = 24), respectively. HAdV co-infection with other respiratory viruses was frequent (infection rates: Northern China, 90.4%; Eastern China, 70.8%). The peak seasons for HAdV-B infection was winter and spring. Additionally, members of multiple species (Human mastadenovirus B, C, D and E) were circulating among paediatric patients with SARI, of which HAdV-B (34/52; 65.4%) and HAdV-C (20/24, 83.3%) were the most predominant in Northern and Eastern China, respectively. These findings provide a benchmark for future epidemiology and prevention strategies for HAdV.
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