ReviewNeuron2015
Cellular level brain imaging in behaving mammals: an engineering approach.
Review in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed.
- CRASH2p: Closed-loop Two Photon Imaging in a Freely Moving Animal.bioRxiv : the preprint server for biology · 2024Article
- Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope.Nature communications · 2024Article
- Progress in Structural and Functional In Vivo Imaging of Microglia and Their Application in Health and Disease.Advances in neurobiology · 2024Review
- Using Human-Induced Pluripotent Stem Cell Derived Neurons on Microelectrode Arrays to Model Neurological Disease: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Adaptive optics for optical microscopy [Invited].Biomedical optics express · 2023Review
- Article
- Emerging V1 neuronal ensembles with enhanced connectivity after associative learning.Frontiers in neuroscience · 2023Article
- Article
- Ca2+ imaging of self and other in medial prefrontal cortex during social dominance interactions in a tube test.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Electro-optical mechanically flexible coaxial microprobes for minimally invasive interfacing with intrinsic neural circuits.Nature communications · 2022Article
- Article
- Current approaches to characterize micro- and macroscale circuit mechanisms of Parkinson's disease in rodent models.Experimental neurology · 2022Review
- Review
- Imaging Synaptic Density: The Next Holy Grail of Neuroscience?Frontiers in neuroscience · 2022Review
- The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams.International journal of molecular sciences · 2021Review
- Miniature microscopes for manipulating and recording in vivo brain activity.Microscopy (Oxford, England) · 2021Article
- Emerging imaging methods to study whole-brain function in rodent models.Translational psychiatry · 2021Review
- Head-mounted microendoscopic calcium imaging in dorsal premotor cortex of behaving rhesus macaque.Cell reports · 2021Article
- A dark quencher genetically encodable voltage indicator (dqGEVI) exhibits high fidelity and speed.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Approaches to inferring multi-regional interactions from simultaneous population recordings: Inferring multi-regional interactions from simultaneous population recordings.Current opinion in neurobiology · 2020Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Fluorescence imaging offers expanding capabilities for recording neural dynamics in behaving mammals, including the means to monitor hundreds of cells targeted by genetic type or connectivity, track cells over weeks, densely sample neurons within local microcircuits, study cells too inactive to isolate in extracellular electrical recordings, and visualize activity in dendrites, axons, or dendritic spines. We discuss recent progress and future directions for imaging in behaving mammals from a systems engineering perspective, which seeks holistic consideration of fluorescent indicators, optical instrumentation, and computational analyses. Today, genetically encoded indicators of neural Ca(2+) dynamics are widely used, and those of trans-membrane voltage are rapidly improving. Two complementary imaging paradigms involve conventional microscopes for studying head-restrained animals and head-mounted miniature microscopes for imaging in freely behaving animals. Overall, the field has attained sufficient sophistication that increased cooperation between those designing new indicators, light sources, microscopes, and computational analyses would greatly benefit future progress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.