ReviewNeuron2015
The emergence of single neurons in clinical neurology.
Review in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Trends and hotspots of stereoelectroencephalogram from 2002 to 2023: a bibliometric analysis.Frontiers in neurology · 2024Pooled it
- In situ graphene-seq: spatial transcriptomics and chronic electrophysiological characterization of tissue microenvironments.Nature communications · 2026Article
- Human intracranial correlates of dynamic coding in auditory working memory.bioRxiv : the preprint server for biology · 2026Article
- Electrode Arrays for Detecting and Modulating Deep Brain Neural Information in Primates: A Review.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Simultaneous invasive and non-invasive recordings in humans: A novel Rosetta stone for deciphering brain activity.Journal of neuroscience methods · 2024Review
- Emerging Medical Technologies and Their Use in Bionic Repair and Human Augmentation.Bioengineering (Basel, Switzerland) · 2024Review
- Phase-amplitude coupling detection and analysis of human 2-dimensional neural cultures in multi-well microelectrode array in vitro.Journal of neuroscience methods · 2024Article
- Flexible, scalable, high channel count stereo-electrode for recording in the human brain.Nature communications · 2024Article
- Modified Neuropixels probes for recording human neurophysiology in the operating room.Nature protocols · 2023Review
- Stitching Flexible Electronics into the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring.Cell reports · 2023Article
- Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces.MRS bulletin · 2023Article
- Local neuronal excitation and global inhibition during epileptic fast ripples in humans.Brain : a journal of neurology · 2023Article
- Translational Organic Neural Interface Devices at Single Neuron Resolution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- An Ultra-Low-Noise, Low Power and Miniaturized Dual-Channel Wireless Neural Recording Microsystem.Biosensors · 2022Article
- Scalable Thousand Channel Penetrating Microneedle Arrays on Flex for Multimodal and Large Area Coverage BrainMachine Interfaces.Advanced functional materials · 2022Article
- Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex.Nature neuroscience · 2022Article
- Neurons as will and representation.Nature reviews. Neuroscience · 2022Review
- Microfluidic platforms for single neuron analysis.Materials today. Bio · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Single neuron actions and interactions are the sine qua non of brain function, and nearly all diseases and injuries of the CNS trace their clinical sequelae to neuronal dysfunction or failure. Remarkably, discussion of neuronal activity is largely absent in clinical neuroscience. Advances in neurotechnology and computational capabilities, accompanied by shifts in theoretical frameworks, have led to renewed interest in the information represented by single neurons. Using direct interfaces with the nervous system, millisecond-scale information will soon be extracted from single neurons in clinical environments, supporting personalized treatment of neurologic and psychiatric disease. In this Perspective, we focus on single-neuronal activity in restoring communication and motor control in patients suffering from devastating neurological injuries. We also explore the single neuron's role in epilepsy and movement disorders, surgical anesthesia, and in cognitive processes disrupted in neurodegenerative and neuropsychiatric disease. Finally, we speculate on how technological advances will revolutionize neurotherapeutics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.