ArticlePloS one2015
Let-7, mir-98 and mir-183 as biomarkers for cancer and schizophrenia [corrected].
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Janus kinase/signal transducer and activator of transcription pathway in schizophrenia (Review).Biomedical reports · 2026Review
- Inhibition of MicroRNA-182/183 Cluster Ameliorates Schizophrenia by Activating the Axon Guidance Pathway and Upregulating DCC.Oxidative medicine and cellular longevity · 2022Article
- The Effect of miR-98 and miR-214 on Apoptotic and Angiogenic Pathways in Hepatocellular Carcinoma HepG2 Cells.Indian journal of clinical biochemistry : IJCB · 2020Article
- Brain-derived neurotrophic factor and mental disorders.Biomedical journal · 2020Review
- Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes.RNA biology · 2020Article
- MicroRNA-183-5p: A New Potential Marker for Prostate Cancer.Indian journal of clinical biochemistry : IJCB · 2019Article
- Screening of schizophrenia associated miRNAs and the regulation of miR-320a-3p on integrin β1.Medicine · 2019Article
- MiR-98 modulates macrophage polarization and suppresses the effects of tumor-associated macrophages on promoting invasion and epithelial-mesenchymal transition of hepatocellular carcinoma.Cancer cell international · 2018Article
- MicroRNA-98 Plays a Suppressive Role in Non-Small Cell Lung Cancer Through Inhibition of SALL4 Protein Expression.Oncology research · 2017Article
- MiR-98 inhibits malignant progression via targeting MTDH in squamous cell carcinoma of the head and neck.American journal of cancer research · 2017Article
- MicroRNA expression profiles in chronic epilepsy rats and neuroprotection from seizures by targeting miR-344a.Neuropsychiatric disease and treatment · 2017Article
- miRNAs and their role in the correlation between schizophrenia and cancer (Review).Molecular medicine reports · 2016Review
- MicroRNA-98 acts as a tumor suppressor in hepatocellular carcinoma via targeting SALL4.Oncotarget · 2016Article
- MicroRNAs as biomarkers for major depression: a role for let-7b and let-7c.Translational psychiatry · 2016Article
- MiR181c inhibits ovarian cancer metastasis and progression by targeting PRKCD expression.International journal of clinical and experimental medicine · 2015Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence supports a role of microRNAs in cancer and psychiatric disorders such as schizophrenia and bipolar disorder, through their regulatory role on the expression of multiple genes. The rather rare co-morbidity of cancer and schizophrenia is an old hypothesis which needs further research on microRNAs as molecules that might exert their oncosuppressive or oncogenic activity in the context of their role in psychiatric disorders. The expression pattern of a variety of different microRNAs was investigated in patients (N = 6) suffering from schizophrenia termed control, patients with a solid tumor (N = 10) and patients with both schizophrenia and tumor (N = 8). miRNA profiling was performed on whole blood samples using the miRCURY LNA microRNA Array technology (6th & 7th generation). A subset of 3 microRNAs showed a statistically significant differential expression between the control and the study groups. Specifically, significant down-regulation of the let-7p-5p, miR-98-5p and of miR-183-5p in the study groups (tumor alone and tumorand schizophrenia) was observed (p<0.05). The results of the present study showed that let-7, miR-98 and miR-183 may play an important oncosuppressive role through their regulatory impact in gene expression irrespective of the presence of schizophrenia, although a larger sample size is required to validate these results. Nevertheless, further studies are warranted in order to highlight a possible role of these and other micro-RNAs in the molecular pathways of schizophrenia.
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