ArticlePloS one2015
A comparison of genome-wide DNA methylation patterns between different vascular tissues from patients with coronary heart disease.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites.Clinical epigenetics · 2023Pooled it
- The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis.Clinical epigenetics · 2019Pooled it
- DNA hydroxymethylation combined with carotid plaques as a novel biomarker for coronary atherosclerosis.Aging · 2019Trial
- DNA methylation differences in monozygotic twins with Van der Woude syndrome.Frontiers in dental medicine · 2023Article
- Connections between cross-tissue and intra-tissue biomarkers of aging biology in older adults.Epigenetics communications · 2023Article
- DNA methylation profiling reveals novel pathway implicated in cardiovascular diseases of diabetes.Frontiers in endocrinology · 2023Article
- DNA Methylation Alterations in Fractionally Irradiated Rats and Breast Cancer Patients Receiving Radiotherapy.International journal of molecular sciences · 2022Article
- Article
- ABCA1 and ABCG1 DNA methylation in epicardial adipose tissue of patients with coronary artery disease.BMC cardiovascular disorders · 2021Article
- DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies.Clinical epigenetics · 2021Review
- Atherosclerosis prediction by microarray-based DNA methylation analysis.Experimental and therapeutic medicine · 2020Article
- Epigenetic predictors of all-cause mortality are associated with objective measures of neighborhood disadvantage in an urban population.Clinical epigenetics · 2020Article
- Identification of Potential Biomarkers for CAD Using Integrated Expression and Methylation Data.Frontiers in genetics · 2020Article
- Characterization of Blood Surrogate Immune-Methylation Biomarkers for Immune Cell Infiltration in Chronic Inflammaging Disorders.Frontiers in genetics · 2019Article
- Article
- Comparative molecular characterization of typical and exceptional responders in glioblastoma.Oncotarget · 2018Article
- Article
- Transcription Factor Co-expression Networks of Adipose RNA-Seq Data Reveal Regulatory Mechanisms of Obesity.Current genomics · 2018Article
- msgbsR: An R package for analysing methylation-sensitive restriction enzyme sequencing data.Scientific reports · 2018Article
- Genome-wide DNA methylome alterations in acute coronary syndrome.International journal of molecular medicine · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic mechanisms of gene regulation in context of cardiovascular diseases are of considerable interest. So far, our current knowledge of the DNA methylation profiles for atherosclerosis affected and healthy human vascular tissues is still limited. Using the Illumina Infinium Human Methylation27 BeadChip, we performed a genome-wide analysis of DNA methylation in right coronary artery in the area of advanced atherosclerotic plaques, atherosclerotic-resistant internal mammary arteries, and great saphenous veins obtained from same patients with coronary heart disease. The resulting DNA methylation patterns were markedly different between all the vascular tissues. The genes hypomethylated in athero-prone arteries to compare with atherosclerotic-resistant arteries were predominately involved in regulation of inflammation and immune processes, as well as development. The great saphenous veins exhibited an increase of the DNA methylation age in comparison to the internal mammary arteries. Gene ontology analysis for genes harboring hypermethylated CpG-sites in veins revealed the enrichment for biological processes associated with the development. Four CpG-sites located within the MIR10B gene sequence and about 1 kb upstream of the HOXD4 gene were also confirmed as hypomethylated in the independent dataset of the right coronary arteries in the area of advanced atherosclerotic plaques in comparison with the other vascular tissues. The DNA methylation differences observed in vascular tissues of patients with coronary heart disease can provide new insights into the mechanisms underlying the development of pathology and explanation for the difference in graft patency after coronary artery bypass grafting surgery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.