ArticleSpine2015
Paraspinal Muscle Spindle Response to Intervertebral Fixation and Segmental Thrust Level During Spinal Manipulation in an Animal Model.
Article in Spine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The importance of selecting the correct site to apply spinal manipulation when treating spinal pain: Myth or reality? A systematic review.Scientific reports · 2021Pooled it
- Trial
- Mechanical transmission of impulsive instrument-assisted spinal manipulation: contact-site-dependent biomechanical coupling in theFrontiers in bioengineering and biotechnology · 2026Article
- Neuroplastic Responses to Chiropractic Care: Broad Impacts on Pain, Mood, Sleep, and Quality of Life.Brain sciences · 2024Article
- In vivo measurement of intradiscal pressure changes related to thrust and non-thrust spinal manipulation in an animal model: a pilot study.Chiropractic & manual therapies · 2022Article
- The contemporary model of vertebral column joint dysfunction and impact of high-velocity, low-amplitude controlled vertebral thrusts on neuromuscular function.European journal of applied physiology · 2021Review
- Influence of Intervertebral Fixation and Segmental Thrust Level on Immediate Post-Spinal Manipulation Trunk Muscle Spindle Response in an Animal Model.Brain sciences · 2021Article
- Effects of Thrust Magnitude and Duration on Immediate Postspinal Manipulation Trunk Muscle Spindle Responses.Journal of manipulative and physiological therapeutics · 2021Article
- Force Distribution Within Spinal Tissues During Posterior to Anterior Spinal Manipulative Therapy: A Secondary Analysis.Frontiers in integrative neuroscience · 2021Article
- Beliefs, perceptions and practices of chiropractors and patients about mitigation strategies for benign adverse events after spinal manipulation therapy.Chiropractic & manual therapies · 2020Article
- Physiological Responses Induced by Manual Therapy in Animal Models: A Scoping Review.Frontiers in neuroscience · 2020Article
- Increased Voluntary Activation of the Elbow Flexors Following a Single Session of Spinal Manipulation in a Subclinical Neck Pain Population.Brain sciences · 2019Article
- Spinal manipulation frequency and dosage effects on clinical and physiological outcomes: a scoping review.Chiropractic & manual therapies · 2019Article
- Article
- Characteristics of Paraspinal Muscle Spindle Response to Mechanically Assisted Spinal Manipulation: A Preliminary Report.Journal of manipulative and physiological therapeuticsArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
designIn vivo cat model study.
objectiveTo determine whether intervertebral facet joint fixation and segmental thrust level alter paraspinal muscle spindle activity during simulated spinal manipulation. SUMMARY OF BACKGROUND DATA: Intervertebral motion is commonly assessed by manual therapy practitioners during clinical evaluation and treatment. Mechanoreceptor activity elicited during spinal manipulation has been theorized as a potential mechanism of its efficacy. The degree to which intervertebral fixation and segmental thrust level alter paraspinal muscle spindle activity during high velocity low amplitude spinal manipulation (HVLA-SM) is unclear.
methodsIntervertebral fixation was created by inserting facet screws through the left L(5-6) and L(6-7) and left L(4-5), L(5-6), and L(6-7) facet joints of a cat spine. Changes in the mean instantaneous frequency of L6 muscle spindle discharge were determined during 5 HVLA-SM thrust durations (0-control, 75, 100, 150, 250 ms) delivered at the L4 or L6 spinous process in each of the 3 conditions within the same preparation: laminectomy-only (surgical control; n = 23), L(5-6) and L(6-7) fixations (n = 20), and L(4-5), L(5-6), and L(6-7) fixations (n = 7). Comparisons were made between thrust levels, thrust durations, and spinal joint conditions using a linear mixed model.
resultsInsertion of facet screws compared with laminectomy-only significantly increased (P < 0.001) lumbar spinal stiffness during L6 HVLA-SM. Compared with laminectomy-only, both the 2 facet screw (100 ms; P < 0.05) and 3 screw conditions [75 ms and 100 ms (P < 0.001), 150 ms (P < 0.005), and 250 ms (P < 0.05)] significantly decreased L6 spindle response during the L6 HVLA-SM. HVLA-SM-delivered 2 segments rostral to the level of muscle spindle input significantly decreases spindle response compared with HVLA-SM-delivered at-level; however, nontarget HVLA-SM still elicits 60% to 80% of at-level muscle spindle response.
conclusionIntervertebral fixation decreases paraspinal muscle spindle response during L6 HVLA-SM in a cat model. Whereas HVLA-SM target accuracy maximizes spindle response, nontarget HVLA-SM still elicits substantial levels of muscle spindle activity. LEVEL OF EVIDENCE: N/A.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.