ArticlePediatric research2015
Why do children decide not to participate in clinical research: a quantitative and qualitative study.
Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Experiences and perspectives of children and adolescents participating in pediatric clinical trials: a qualitative evidence synthesis.Archives of public health = Archives belges de sante publique · 2026Pooled it
- Participation of children and adolescents in healthcare, prevention and health research: A dot survey.PloS one · 2026Article
- Uptake of core outcome sets in paediatric clinical trials: a protocol.BMJ paediatrics open · 2025Article
- Introducing youth to clinical research: Development and pilot implementation of a children's activity book.Journal of clinical and translational science · 2025Article
- Shining a spotlight on the inclusion of disabled participants in clinical trials: a mixed methods study.Trials · 2024Article
- From opt-out to opt-in consent for secondary use of medical data and residual biomaterial: An evaluation using the RE-AIM framework.PloS one · 2024Article
- Taking Risks to Protect Others-Pediatric Vaccination and Moral Responsibility.Public health ethics · 2023Article
- Pediatric patient engagement in clinical care, research and intervention development: a scoping review.Journal of patient-reported outcomes · 2023Article
- Article
- Monitoring the recovery time of children after tonsillectomy using commercial activity trackers.European journal of pediatrics · 2021Observational
- Patient and caregiver engagement in research: factors that influence co-enrollment in research.Pediatric rheumatology online journal · 2019Article
- Researching the Experiences of Children with Cancer: Considerations for Practice.Children (Basel, Switzerland) · 2019Review
- The challenges of research participation by children.Pediatric research · 2015Article
Corrections and comments
- Commented on by
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMore pediatric drug trials are needed, but although specific pediatric regulations warrant safety, recruitment of children for these trials remains one of the main difficulties. Therefore, we investigated potential determining factors of nonparticipation in clinical research, in order to optimize research participation of children by recommending improved recruitment strategies.
methodsBetween 1 January 2012 and 1 January 2014, we performed a prospective study among161 pediatric patients, aged 6 to 18 y, who were eligible for clinical research. We quantitatively analyzed the association of potential explanatory variables (e.g., age, cognitive development, experience, ethnicity) with nonparticipation and qualitatively analyzed interviews on reasons for nonparticipation.
resultsSixty percent of the children did not participate in the research project on offer (39% decided not to participate, 21% were indecisive). Lower age, less disease experience, and less complex research with lower risk were predictive for not participating. Time constraint and extra burden were expressed as decisive reasons for not participating.
conclusionsStrategies to optimize research participation should be aimed at younger children and their families, who are logistically challenged and unfamiliar with health care and research. Recommendations include informing pediatric patients and their families of the value of research; minimizing logistic burdens; and improving accessibility.
Indexed as
Identifiers
25856170What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.