ArticlePloS one2015
Preterm prelabor rupture of membranes and outcome of very-low-birth-weight infants in the German Neonatal Network.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 67 citations in OpenAlex.
- Vaginal Fluid Creatinine Levels to Detect Rupture of Membranes.Journal of obstetrics and gynaecology of India · 2025Article
- Does Preterm Prolonged Rupture of Membranes Increase the Risk of Needing Invasive Respiratory Support? A Retrospective Single-Centre Study.Children (Basel, Switzerland) · 2024Article
- Pain/Stress, Mitochondrial Dysfunction, and Neurodevelopment in Preterm Infants.Developmental neuroscience · 2024Article
- Adverse fetal birth outcomes and its associated factors among mothers with premature rupture of membrane in Amhara region, Ethiopia.PloS one · 2024Article
- Article
- The demand for intermittent preventive treatment of malaria in pregnancy using sulfadoxine-pyrimethamine in the Volta Region of Ghana.PloS one · 2024Article
- Article
- Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis.BMC medicine · 2023Article
- Impact of premature rupture of membranes on clinical outcomes of extremely premature infants: A propensity score matching study.Frontiers in pediatrics · 2023Article
- Article
- Restrictive prescription of antibiotics in preterm infants with premature rupture of membranes.BMC pediatrics · 2022Article
- Latency duration of preterm premature rupture of membranes and neonatal outcome: a retrospective single-center experience.European journal of pediatrics · 2022Article
- Clinical Early-Onset Sepsis Is Equally Valid to Culture-Proven Sepsis in Predicting Outcome in Infants after Preterm Rupture of Membranes.Journal of clinical medicine · 2021Article
- Calendar age and puberty-related development of regional gray matter volume and white matter tracts during adolescence.Brain structure & function · 2021Article
- Risk factors for neonatal bronchopulmonary dysplasia in extremely preterm premature rupture of membranes: a retrospective study.BMC pregnancy and childbirth · 2020Article
- Bronchopulmonary dysplasia frequency and risk factors in very low birth weight infants: A 3-year retrospective study.Northern clinics of Istanbul · 2020Article
- Neonatal Outcome After Preeclampsia and HELLP Syndrome: A Population-Based Cohort Study in Germany.Frontiers in pediatrics · 2020Article
- Increased Regulatory T Cells Precede the Development of Bronchopulmonary Dysplasia in Preterm Infants.Frontiers in immunology · 2020Observational
Corrections and comments
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Authors and funding
19 authors at 11 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIt was the aim of our study to evaluate the independent effect of preterm prelabor rupture of membranes (PPROM) as a cause of preterm delivery on mortality during primary hospital stay and significant morbidities in very-low-birth-weight (VLBW) infants < 32 weeks of gestation.
designObservational, epidemiological study design.
settingPopulation-based cohort, German Neonatal Network (GNN). POPULATION: 6102 VLBW infants were enrolled in GNN from 2009-2012, n=4120 fulfilled criteria for primary analysis (< 32 gestational weeks, no pre-eclampsia, HELLP (highly elevated liver enzymes and low platelets syndrome) or placental abruption as cause of preterm birth).
methodsMultivariable logistic regression analyses included PPROM as potential risk factors for adverse outcomes and well established items such as gestational age in weeks, birth weight, antenatal steroids, center, inborn delivery, multiple birth, gender and being small-for-gestational-age.
resultsPPROM as cause of preterm delivery had no independent effect on the risk of early-onset sepsis, clinical sepsis and blood-culture proven sepsis, while gestational age proved to be the most important contributor to sepsis risk. The diagnosis of PPROM was associated with an increased risk for bronchopulmonary dysplasia (BPD; OR: 1.25, 95% CI: 1.02-1.55, p=0.03) but not with other major outcomes.
conclusionsThe diagnosis of PPROM per se is not associated with adverse outcome in VLBW infants < 32 weeks apart from a moderately increased risk for BPD. Randomized controlled trials with primary neonatal outcomes are needed to determine which subgroup of VLBW infants benefit from expectant or intentional management of PPROM.
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