ArticleCell death & disease2015
The canonical Wg signaling modulates Bsk-mediated cell death in Drosophila.
Article in Cell death & disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Slik maintains tissue homeostasis by preventing JNK-mediated apoptosis.Cell division · 2023Article
- Dysfunction of lipid storage droplet-2 suppresses endoreplication and induces JNK pathway-mediated apoptotic cell death in Drosophila salivary glands.Scientific reports · 2022Article
- Genome-Wide Analysis inGenes · 2022Article
- JNK Signaling inInternational journal of molecular sciences · 2021Review
- Chk2-p53 and JNK in irradiation-induced cell death of hematopoietic progenitors and differentiated cells in Drosophila larval lymph gland.Biology open · 2021Article
- Global chromatin organizer SATB1 acts as a context-dependent regulator of the Wnt/Wg target genes.Scientific reports · 2021Article
- Review
- Snail modulates JNK-mediated cell death in Drosophila.Cell death & disease · 2019Article
- ADAMTS Sol narae cleaves extracellular Wingless to generate a novel active form that regulates cell proliferation in Drosophila.Cell death & disease · 2019Article
- Article
- Article
- GLYAT regulates JNK-mediated cell death in Drosophila.Scientific reports · 2017Article
- dFoxO promotes Wingless signaling in Drosophila.Scientific reports · 2016Article
- Pelle Modulates dFoxO-Mediated Cell Death in Drosophila.PLoS genetics · 2015Article
- Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila.BioMed research international · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell death is an essential regulatory mechanism for removing unneeded cells in animal development and tissue homeostasis. The c-Jun N-terminal kinase (JNK) pathway has pivotal roles in the regulation of cell death in response to various intrinsic and extrinsic stress signals. The canonical Wingless (Wg) signaling has been implicated in cell proliferation and cell fate decisions, whereas its role in cell death remains largely elusive. Here, we report that activated Bsk (the Drosophila JNK homolog) induced cell death is mediated by the canonical Wg signaling. First, loss of Wg signaling abrogates Bsk-mediated caspase-independent cell death. Second, activation of Wg signaling promotes cell death in a caspase-independent manner. Third, activation of Bsk signaling results in upregulated transcription of wingless (wg) gene. Finally, Wg pathway participates in the physiological function of Bsk signaling in development. These findings not only reveal a previously undiscovered role of Wg signaling in Bsk-mediated cell death, but also provide a novel mechanism for the interplay between the two important signaling pathways in development.
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