ArticleCritical care medicine2015
The Association Between Nutritional Adequacy and Long-Term Outcomes in Critically Ill Patients Requiring Prolonged Mechanical Ventilation: A Multicenter Cohort Study.
Article in Critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 56 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feeding With Indirect Calorimetry and Cycling in the Elderly Intensive Care Patient
Evaluation of Nutritional Practices in the Critical Care Patient at the Intensive Care Unit
The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry-based Randomized Trial: The EFFORT Ultrasound a Sub-study
Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 186 citations in OpenAlex.
- Reporting of nutritional screening, status, and intake in trials of nutritional and physical rehabilitation following critical illness: a systematic review.The American journal of clinical nutrition · 2025Pooled it
- Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without supplemental parenteral nutrition in critically ill adults.The Cochrane database of systematic reviews · 2019Pooled it
- Changes in health-related quality of life after discharge from an intensive care unit: a systematic review.Anaesthesia · 2019Pooled it
- Comparison of electromagnetic navigation-guided and conventional blind nasojejunal tube placement in mechanically ventilated patients: a prospective non-randomized controlled study with two stages.Frontiers in nutrition · 2025Trial
- Optimized calorie and high protein intake versus recommended caloric-protein intake in critically ill patients: a prospective, randomized, controlled phase II clinical trial.Revista Brasileira de terapia intensiva · 2019Trial
- Supplemental parenteral nutrition versus usual care in critically ill adults: a pilot randomized controlled study.Critical care (London, England) · 2018Trial
- First-week caloric intake and 1-year mortality in critically ill medical patients with mechanical ventilation: A retrospective study.Asia Pacific journal of clinical nutrition · 2026Article
- Total cholesterol and bilirubin levels are associated with neurologic outcomes in patients with out-of-hospital cardiac arrest.Internal and emergency medicine · 2025Observational
- A New Perspective on Overfeeding in the Intensive Care Unit (ICU): Challenges, Dangers and Prevention Methods.Life (Basel, Switzerland) · 2025Review
- Article
- Efficiency of IL-6 in Early Prognosis and Follow-Up in Critically Ill Patients with Septic Shock.Diseases (Basel, Switzerland) · 2024Article
- Prolonged weaning from mechanical ventilation: who, what, when and how?Breathe (Sheffield, England) · 2024Review
- Incidence, outcome, and prognostic factors of prolonged mechanical ventilation among children in Chinese mainland: a multi-center survey.Frontiers in pediatrics · 2024Article
- Relevance and application of clinical practice guidelines in different settings.The Southern African journal of critical care : the official journal of the Critical Care Society · 2024Article
- Fractal Phototherapy in Maximizing Retina and Brain Plasticity.Advances in neurobiology · 2024Article
- Article
- Metabolic Support in Acute Respiratory Distress Syndrome: A Narrative Review.Journal of clinical medicine · 2023Review
- Association of longitudinal changes in skeletal muscle mass with prognosis and nutritional intake in acutely hospitalized patients with abdominal trauma: a retrospective observational study.Frontiers in nutrition · 2023Article
- The association of macronutrient deficit with functional status at discharge from the intensive care unit: a retrospective study from a single-center critical illness registry.European journal of clinical nutrition · 2022Article
- Association between caloric adequacy and short-term clinical outcomes in critically ill patients using a weight-based equation: Secondary analysis of a cluster-randomized controlled trial.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo examine the association between short-term nutritional adequacy received while in the ICU and long-term outcomes including 6-month survival and health-related quality of life in critically ill patients requiring prolonged mechanical ventilation.
designRetrospective analysis of data prospectively collected in the context of a multicenter randomized controlled trial.
settingAn international sample of ICUs. PATIENTS: Adult patients who were mechanically ventilated for more than 8 days in the ICU.
interventionsNone. MEASUREMENTS AND MAIN
resultsNutritional adequacy was obtained from the average proportion of prescribed calories received over the amount prescribed during the first 8 days. Survival status and health-related quality of life as assessed using the Short-Form 36 v2 were obtained at 3- and 6 months post ICU admission. Of the 1,223 patients enrolled in the randomized controlled trial, 475 met the inclusion criteria for this study. At 6-month follow-up, 302 of the 475 patients (64%) were alive. Survival time in those who received low nutritional adequacy was significantly shorter than those who received high nutritional adequacy while adjusting for important covariates (adjusted hazard ratio, 1.7; 95% CI, 1.1-2.6). At 3-month follow-up, a 25% increase in nutritional adequacy was associated with improvements in Physical Functioning and Role Physical of 7.3 (p = 0.02) and 8.3 (p = 0.004) points, respectively. At 6-month follow-up, adjusted increases in Physical Functioning and Role Physical scores for every 25% increase in nutrition adequacy became smaller and were no longer statistically significant (adjusted estimate for Physical Functioning = 4.2, p = 0.14; for Role Physical = 3.2, p = 0.25).
conclusionsGreater amounts of nutritional intake received during the first week in the ICU were associated with longer survival time and faster physical recovery to 3 months but not 6 months post ICU discharge in critically ill patients requiring prolonged mechanical ventilation. Current recommendations to underfeed critically ill patients may cause harm in some long-stay patients.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.