ArticleCanadian journal of gastroenterology & hepatology2015
Noninvasive methods, including transient elastography, for the detection of liver disease in adults with cystic fibrosis.
Article in Canadian journal of gastroenterology & hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Non-invasive Diagnostic Tests in Cystic Fibrosis-Related Liver Disease: A Diagnostic Test Accuracy Network Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Interventions for preventing and managing advanced liver disease in cystic fibrosis.The Cochrane database of systematic reviews · 2020Pooled it
- Interventions for preventing and managing advanced liver disease in cystic fibrosis.The Cochrane database of systematic reviews · 2017Pooled it
- Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update.Hepatology international · 2017Guideline
- Prospective study of quantitative liver MRI in cystic fibrosis: feasibility and comparison to PUSH cohort ultrasound.Pediatric radiology · 2023Trial
- Evaluating the Diagnostic Potential of the FIB-4 Index for Cystic Fibrosis-Associated Liver Disease in Adults: A Comparison with Transient Elastography.Journal of clinical medicine · 2025Article
- Integration of Non-invasive Screening for Cystic Fibrosis Related Liver Disease in the Regular Follow-Up for Cystic Fibrosis.Digestive diseases and sciences · 2025Article
- Diagnosis, Management, and Prognosis of Cystic Fibrosis-Related Liver Disease in Children.Diagnostics (Basel, Switzerland) · 2024Review
- Improving detection of cystic fibrosis related liver disease using liver fibrosis assessment tools.Heliyon · 2023Article
- Assessment of Liver Fibrosis with the Use of Elastography in Paediatric Patients with Diagnosed Cystic Fibrosis.Disease markers · 2022Article
- Role of transient elastography and APRI in the assessment of pediatric cystic fibrosis liver disease.Canadian liver journal · 2021Article
- Review: Pathogenesis of cholestatic liver diseases.World journal of hepatology · 2020Review
- Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.Mediators of inflammation · 2020Article
- Transient Elastography in the Evaluation of Cystic Fibrosis-Associated Liver Disease: Systematic Review and Meta-analysis.Journal of the Canadian Association of Gastroenterology · 2019Article
- Cystic fibrosis liver disease: A condition in need of structured transition and continuity of care.Canadian liver journal · 2019Review
- Adult-onset cystic fibrosis liver disease: Diagnosis and characterization of an underappreciated entity.Hepatology (Baltimore, Md.) · 2017Article
- Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients.Frontiers in cardiovascular medicine · 2017Article
- A quantitative metabolomics profiling approach for the noninvasive assessment of liver histology in patients with chronic hepatitis C.Clinical and translational medicine · 2016Article
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6 authors.
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Abstract
backgroundLiver disease is the third leading cause of mortality in patients with cystic fibrosis (CF). However, detection of CF-associated liver disease (CFLD) is challenging.
objectiveTo evaluate the diagnostic performance of noninvasive methods for the detection of CFLD with a focus on transient elastography (TE).
methodsPatients at the Adult CF Clinic of Calgary and Southern Alberta (n=127) underwent liver stiffness measurement (LSM) by TE using the FibroScan (FS, Ecosens, France) M probe; aspartate aminotransferase to platelet ratio index (APRI) and FibroTest (FT) scores were also calculated. The diagnostic performance of these tools for the detection of CFLD (defined as two or more the following criteria: abnormal liver biochemistry, hepatomegaly or sonographic abnormalities other than steatosis) were compared using the area under ROC curves.
resultsForty-seven percent of the cohort was male. The median age was 27 years (interquartile range [IQR] 22 to 37 years) and body mass index 21 kg⁄m(2) (IQR 19 kg⁄m(2) to 23 kg⁄m(2)); 25% of patients were on ursodeoxycholic acid and 12% had undergone lung transplantation. The prevalence of CFLD was 14% (n=18). FS was successful in all patients; one (0.8%) patient had poorly reliable results (IQR⁄M >30% and LSM ≥7.1 kPa). Compared with patients without CFLD (n=109), individuals with CFLD had higher median LSM according to FS (3.9 kPa [IQR 3.4 to 4.9 kPa] versus 6.4 kPa [IQR 4.4 to 8.0 kPa]), APRI (0.24 [IQR 0.17 to 0.31] versus 0.50 [IQR 0.22 to 1.18]) and FT scores (0.08 [IQR 0.05 to 1.5] versus 0.18 [IQR 0.11 to 0.35]; all P<0.05). Area under ROC curve for FS, APRI and FT for the detection of CFLD were 0.78 (95% CI 0.65 to 0.92), 0.72 (95% CI 0.56 to 0.87) and 0.76 (95% CI 0.62 to 0.90) (P not significant). At a threshold of >5.2 kPa, the sensitivity, specificity, positive and negative predictive values of LSM according to FS for detecting CFLD were 67%, 83%, 40% and 94%, respectively.
conclusionsFS, APRI and FT were useful noninvasive methods for detecting CFLD in adults.
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