ArticleJournal of the American Society of Nephrology : JASN2015
Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery.
Article in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
102 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Biomarkers for assessing acute kidney injury for people who are being considered for admission to critical care: a systematic review and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2022Pooled it
- Prediction of key regulators and downstream targets of E. coli induced mastitis.Journal of applied genetics · 2019Pooled it
- Effects of Liposomal Bupivacaine for Superficial Parasternial Intercostal Plane Block on Postoperative Stress and Analgesia in Patients Undergoing Median Sternotomy: A Prospective, Randomized, Double-Blind Trial.Drug design, development and therapy · 2026Trial
- A randomized double-blind, placebo-controlled clinical phase IIa trial on safety, immunomodulatory effects and pharmacokinetics of EA-230 during experimental human endotoxaemia.British journal of clinical pharmacology · 2019Trial
- Long-Term Clinical Outcomes after Early Initiation of RRT in Critically Ill Patients with AKI.Journal of the American Society of Nephrology : JASN · 2018Trial
- High-Density Lipoprotein Cholesterol Concentration and Acute Kidney Injury After Cardiac Surgery.Journal of the American Heart Association · 2017Trial
- Effect of hemoadsorption during cardiopulmonary bypass surgery - a blinded, randomized, controlled pilot study using a novel adsorbent.Critical care (London, England) · 2016Trial
- The Prognostic Value of Inflammatory Markers in Paediatric Acute Kidney Injury.Journal of clinical medicine · 2026Article
- Preventing Cardiac Surgery-Associated Acute Kidney Injury with the 4-B Approach: Biomarkers, Bundles, Blood Purification, and Blockage of the Complement Cascade.Cardiorenal medicine · 2026Article
- Acute kidney injury and postoperative delirium.Journal of biomedical research · 2025Article
- [Focus on sepsis and general intensive care medicine 2024/2025 : Summary of selected intensive medical care studies].Die Anaesthesiologie · 2025Article
- Effect of On-Pump Versus Off-Pump Surgery on the Renal Function of Diabetic Patients: A Systematic Review.Cureus · 2025Review
- Tracking inflammation status for improving patient prognosis: A review of current methods, unmet clinical needs and opportunities.Biotechnology advances · 2025Review
- Cell-free mitochondrial DNA may predict the risk of post-operative complications and outcomes in surgical aortic valve replacement patients.Scientific reports · 2025Article
- Brief Report: Preadmission VACS Index as a Predictor of Hospital Acute Kidney Injury in People With HIV.Journal of acquired immune deficiency syndromes (1999) · 2025Observational
- Early recovery of leukocyte subsets is associated with favorable progression-free survival in patients with inoperable stage II/III NSCLC after multimodal treatment: a prospective explorative study.Radiation oncology (London, England) · 2025Article
- Imputation of missing clock times - application to procalcitonin concentration time course after birth.Journal of pharmacokinetics and pharmacodynamics · 2025Article
- Is High-Dose Ubiquinone Therapy Before Cardiac Surgery Enough to Reduce the Incidence of Cardiac Surgery-Associated Acute Kidney Injury? A Randomized Controlled Trial.Antioxidants (Basel, Switzerland) · 2025Article
- Identifying Water-Salt Homeostasis and Inflammatory Response in Pathological Cardiac Surgery-Associated Acute Kidney Injury: NT-proBNP-related lncRNAs and miRNAs as Novel Diagnostic Biomarkers and Therapeutic Targets.International journal of medical sciences · 2025Article
- Polymorphisms in rs2069845 are associated with IL-6 and soluble IL-6 receptor levels during total joint replacement.PloS one · 2025Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Inflammation has an integral role in the pathophysiology of AKI. We investigated the associations of two biomarkers of inflammation, plasma IL-6 and IL-10, with AKI and mortality in adults undergoing cardiac surgery. Patients were enrolled at six academic centers (n = 960). AKI was defined as a ≥ 50% or ≥ 0.3-mg/dl increase in serum creatinine from baseline. Pre- and postoperative IL-6 and IL-10 concentrations were categorized into tertiles and evaluated for associations with outcomes of in-hospital AKI or postdischarge all-cause mortality at a median of 3 years after surgery. Preoperative concentrations of IL-6 and IL-10 were not significantly associated with AKI or mortality. Elevated first postoperative IL-6 concentration was significantly associated with higher risk of AKI, and the risk increased in a dose-dependent manner (second tertile adjusted odds ratio [OR], 1.61 [95% confidence interval (95% CI), 1.10 to 2.36]; third tertile adjusted OR, 2.13 [95% CI, 1.45 to 3.13]). First postoperative IL-6 concentration was not associated with risk of mortality; however, the second tertile of peak IL-6 concentration was significantly associated with lower risk of mortality (adjusted hazard ratio, 0.75 [95% CI, 0.57 to 0.99]). Elevated first postoperative IL-10 concentration was significantly associated with higher risk of AKI (adjusted OR, 1.57 [95% CI, 1.04 to 2.38]) and lower risk of mortality (adjusted HR, 0.72 [95% CI, 0.56 to 0.93]). There was a significant interaction between the concentration of neutrophil gelatinase-associated lipocalin, an established AKI biomarker, and the association of IL-10 concentration with mortality (P = 0.01). These findings suggest plasma IL-6 and IL-10 may serve as biomarkers for perioperative outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.