ArticleAmerican journal of epidemiology2015
Associations of the Ratios of n-3 to n-6 Dietary Fatty Acids With Longitudinal Changes in Depressive Symptoms Among US Women.
Article in American journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Blood Fatty Acid Profile as a Predictor of Antidepressant Efficacy-A Prospective Cohort Pilot Study Protocol.Journal of clinical medicine · 2026Article
- Association between plasma polyunsaturated fatty acids and depressive among US adults.Frontiers in nutrition · 2024Article
- Correlations between omega-3 fatty acids and inflammatory/glial abnormalities: the involvement of the membrane and neurotransmitter dysfunction in schizophrenia.Frontiers in cellular neuroscience · 2023Article
- Association of Antioxidant Vitamins A, C, E and Carotenoids with Cognitive Performance over Time: A Cohort Study of Middle-Aged Adults.Nutrients · 2020Article
- Systemic inflammation is associated with depressive symptoms differentially by sex and race: a longitudinal study of urban adults.Molecular psychiatry · 2020Article
- Associations of n-3, n-6 Fatty Acids Intakes and n-6:n-3 Ratio with the Risk of Depressive Symptoms: NHANES 2009-2016.Nutrients · 2020Article
- Association between epigenetic age acceleration and depressive symptoms in a prospective cohort study of urban-dwelling adults.Journal of affective disorders · 2019Article
- Longitudinal Association betweenNutrients · 2018Article
- Higher dietary glycemic index, but not glycemic load, is associated with a lower prevalence of depressive symptoms in a cross-sectional study of young and middle-aged Japanese women.European journal of nutrition · 2018Article
- Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders.Journal of inherited metabolic disease · 2018Review
- Fatty Acids in Ten Species of Fish Commonly Consumed by the Anishinaabe of the Upper Great Lakes.Journal of Great Lakes research · 2018Article
- Site-Specific Fat-1 Knock-In Enables Significant Decrease of n-6PUFAs/n-3PUFAs Ratio in Pigs.G3 (Bethesda, Md.) · 2018Article
- Dairy product consumption and its association with metabolic disturbance in a prospective study of urban adults.The British journal of nutrition · 2018Article
- Polyunsaturated fatty acid composition and childhood adversity: Independent correlates of depressive symptom persistence.Psychiatry research · 2017Article
- Targeted quantification of lipid mediators in skeletal muscles using restricted access media-based trap-and-elute liquid chromatography-mass spectrometry.Analytica chimica acta · 2017Article
- The Role of Lipid Biomarkers in Major Depression.Healthcare (Basel, Switzerland) · 2017Review
- Altered serum fatty acid composition in geriatric depression.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- White blood cell inflammatory markers are associated with depressive symptoms in a longitudinal study of urban adults.Translational psychiatry · 2016Article
- Maternal Malnutrition in the Etiopathogenesis of Psychiatric Diseases: Role of Polyunsaturated Fatty Acids.Brain sciences · 2016Review
- Trans fatty acid intake is related to emotional affect in the Adventist Health Study-2.Nutrition research (New York, N.Y.) · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In the present study, we examined longitudinal changes in self-reported depressive symptoms (and related domains) in relation to baseline intakes of n-3 fatty acids (absolute and relative to n-6 fatty acids). Sex-specific associations were evaluated in a prospective cohort of adults (n = 2,053) from Baltimore, Maryland, who were 30-64 years of age at baseline and were followed for a mean of 4.65 (standard deviation, 0.93) years (2004-2013). Using mean intakes of n-3 and n-6 fatty acids reported on two 24-hour dietary recalls, we estimated the ratios of n-3 to n-6 fatty acids for both highly unsaturated fatty acids (≥20 carbon atoms) (HUFAs) and polyunsaturated fatty acids (≥18 carbon atoms) (PUFAs). Outcomes included total and domain-specific scores on the 20-item Center for Epidemiologic Studies-Depression scale. Based on mixed-effects regression models, among women, both higher n-3 HUFA:n-6 PUFA and n-3 PUFA:n-6 PUFA ratios were associated with a slower rate of increase in total Center for Epidemiologic Studies-Depression scores over time. Higher n-3 HUFA:n-6 HUFA ratios were associated with slower increases in somatic complaints in men, whereas among women, higher n-3 HUFA:n-6 PUFA and n-3 PUFA:n-6 PUFA ratios were both linked to putative longitudinal improvement in positive affect over time. Among US adults, n-3:n-6 dietary fatty acid ratio was associated with longitudinal changes in depressive symptoms, with a higher ratio linked to a slower increase in depressive symptoms over time, particularly among women.
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