ReviewNature reviews. Cardiology2015
Epidemiology and pathophysiology of Takotsubo syndrome.
Review in Nature reviews. Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
168 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Takotsubo syndrome in patients with myasthenia gravis: a systematic review of previously reported cases.BMC neurology · 2019Pooled it
- Meta-analysis of incidence and outcomes of life-threatening arrhythmias in takotsubo cardiomyopathy.Indian heart journalPooled it
- Takotsubo Syndrome: Clinical and Diagnostic Characteristics of 26 Consecutively Hospitalized Patients Over a Five-Year Period.Cardiology research · 2026Article
- Coronary Microvascular Dysfunction in Takotsubo Syndrome: Subtype-Specific Patterns Revealed by Invasive Assessment.Diagnostics (Basel, Switzerland) · 2026Article
- Observational
- Retrospective Evaluation of Anesthetic-Analgesic Protocols in Cats with and Without Transient Myocardial Thickening Following Gonadectomy.Animals : an open access journal from MDPI · 2026Article
- Associations Between Acute Heat Exposure and Hospitalization for Takotsubo Syndrome in the State of California, 2006 to 2019.Journal of the American Heart Association · 2026Article
- Article
- Association between neutrophil percentage to albumin ratio and mortality in takotsubo syndrome patients: analysis of the MIMIC-IV database.BMC cardiovascular disorders · 2026Article
- Article
- Metformin as a potential therapeutic agent in broken heart syndrome: Targeting AMPK-dependent cardio-protection and microvascular function.Molecular biology reports · 2026Review
- Takotsubo syndrome: pathophysiological insights and innovations in patient care.Nature reviews. Cardiology · 2026Review
- Takotsubo cardiomyopathy in myasthenia gravis: a systematic review of case reports with subtype-based analysis.International journal of emergency medicine · 2026Review
- Takotsubo Syndrome in 2025: Evolving Concepts in Pathophysiology, Diagnosis, and Long-Term Management.Journal of clinical medicine · 2025Review
- Reverse Takotsubo Cardiomyopathy After an Adverse Reaction to Alteplase Treated with Intravenous Epinephrine.Cardiology and therapy · 2025Article
- Article
- Takotsubo syndrome: Unraveling the mystery behind its triggers (Review).International journal of molecular medicine · 2025Review
- Analysis of risk factors for Takotsubo cardiomyopathy in older patients using large-scale medical reimbursement data.Scientific reports · 2025Article
- Hyponatremia in takotsubo syndrome is associated with attenuated in-hospital improvement of left ventricular ejection fraction and higher long-term mortality.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025Article
- Article
108 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
- Commented on by
Authors and funding
3 authors.
Funding
Abstract
Takotsubo syndrome is an acute cardiac syndrome first described in 1990 and characterized by transient left ventricular dysfunction affecting more than one coronary artery territory, often in a circumferential apical, mid-ventricular, or basal distribution. Several pathophysiological explanations have been proposed for this syndrome and its intriguing appearance, and awareness is growing that these explanations might not be mutually exclusive. The reversible apical myocardial dysfunction observed might result from more than one pathophysiological phenomenon. The pathophysiology of Takotsubo syndrome is complex and integrates neuroendocrine physiology, potentially involving the cognitive centres of the brain, and including the hypothalamic-pituitary-adrenal axis. Cardiovascular responses are caused by the sudden sympathetic activation and surge in concentrations of circulating catecholamines. The multiple morphological changes seen in the myocardium match those seen after catecholamine-induced cardiotoxicity. The acute prognosis and recurrence rate are now known to be worse than initially thought, and much still needs to be learned about the epidemiology and the underlying pathophysiology of this fascinating condition in order to improve diagnostic and treatment pathways.
Indexed as
Identifiers
25855605What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.