ArticleAging2015
Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver.
Article in Aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- LGR4: A New Receptor Member in Endocrine and Metabolic Diseases.Endocrine reviews · 2023Review
- Growth hormone receptor gene disruption.Vitamins and hormones · 2023Article
- Sex-specific DNA methylation and associations withEpigenetics · 2022Article
- Imbalance in Sirt1 Alternative Splicing in Response to Chronic Stress during the Adolescence Period in Female Mice.International journal of molecular sciences · 2022Article
- Mice with gene alterations in the GH and IGF family.Pituitary · 2022Review
- Nutrition for Older Athletes: Focus on Sex-Differences.Nutrients · 2021Review
- Review
- A Balanced Act: The Effects of GH-GHR-IGF1 Axis on Mitochondrial Function.Frontiers in cell and developmental biology · 2021Review
- Multiple Roles in Neuroprotection for the Exercise Derived Myokine Irisin.Frontiers in aging neuroscience · 2021Review
- Exercise-Induced Lactate Release Mediates Mitochondrial Biogenesis in the Hippocampus of MiceFrontiers in physiology · 2021Article
- Sex differences in renal mitochondrial function: a hormone-gous opportunity for research.American journal of physiology. Renal physiology · 2020Review
- Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic neurodegeneration.Experimental neurology · 2020Review
- Sex differences in cancer mechanisms.Biology of sex differences · 2020Review
- Sex differences in redox homeostasis in renal disease.Redox biology · 2020Review
- Tissue-Specific GHR Knockout Mice: An Updated Review.Frontiers in endocrinology · 2020Review
- Sex Differences in Cardiac AMP-Activated Protein Kinase Following Exhaustive Exercise.Sports medicine international open · 2020Article
- Article
- Growth Hormone Receptor Gene is Essential for Chicken Mitochondrial Function In Vivo and In Vitro.International journal of molecular sciences · 2019Article
- Testosterone Deficiency Caused by Castration Modulates Mitochondrial Biogenesis Through the AR/PGC1α/TFAM Pathway.Frontiers in genetics · 2019Article
- Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features.Biology of sex differences · 2018Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
Mitochondrial biogenesis is an essential process for cell viability. Mice with disruption of the growth hormone receptor (GHR) gene (Ghr gene) in the liver (LiGHRKO), in contrast to long-lived mice with global deletion of the Ghr gene (GHRKO), are characterized by lack of improved insulin sensitivity and severe hepatic steatosis. Tissue-specific disruption of the GHR in liver results in a mouse model with dramatically altered GH/IGF1 axis. We have previously shown increased levels of key regulators of mitochondrial biogenesis in insulin-sensitive GHRKO mice. The aim of the present study is to assess, using real-time PCR, the gene expression of key regulators of mitochondrial biogenesis (Pgc1α, Ampk, Sirt1, Nrf2 and Mfn2) and a marker of mitochondrial activity (CoxIV) in brains, kidneys and livers of male and female LiGHRKO and wild-type (WT) mice. There were significant differences between males and females. In the brain, expression of Pgc1α, Ampk, Sirt1, Nrf2 and Mfn2 was lower in pooled females compared to pooled males. In the kidneys, expression of Ampk and Sirt1 was also lower in female mice. In the liver, no differences between males and females were observed. Sexual dimorphism may play an important role in regulating the biogenesis of mitochondria.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.