ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015
The effect of spinal cord injury on the neurochemical properties of vagal sensory neurons.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- The physiology of interoception and its adaptive role in consciousness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Enhancing Neuroplasticity via vagus nerve stimulation to improve urinary dysfunction after spinal cord injury: a perspective.Bioelectronic medicine · 2025Review
- Vagal afferent responses to cystometry in rat models of urinary bladder irritation: c-fos immunohistochemistry study.International urology and nephrology · 2024Article
- Review
- The effect of vagotomy on c-fos expression in the reticular formation areas following cystometry in cyclophosphamide-induced cystitis in rats.American journal of clinical and experimental urology · 2023Article
- Effect of T3 Spinal Contusion Injury on Upper Urinary Tract Function.Neurotrauma reports · 2022Article
- Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats.Scientific reports · 2021Article
- Altered physiology of gastrointestinal vagal afferents following neurotrauma.Neural regeneration research · 2021Review
- Chronic, Twice-Daily Dosing of an NK2 Receptor Agonist [LysJournal of neurotrauma · 2020Article
- Purinergic receptor expression and function in rat vagal sensory neurons innervating the stomach.Neuroscience letters · 2019Article
- Effects of vagal neuromodulation on feeding behavior.Brain research · 2018Review
- Improvements in bladder, bowel and sexual outcomes following task-specific locomotor training in human spinal cord injury.PloS one · 2018Article
- Review
- Diurnal blood pressure and urine production in acute spinal cord injury compared with controls.Spinal cord · 2017Observational
- Nociceptive transmission and modulation via P2X receptors in central pain syndrome.Molecular brain · 2016Review
- A review of dorsal root ganglia and primary sensory neuron plasticity mediating inflammatory and chronic neuropathic pain.Neurobiology of pain (Cambridge, Mass.)Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The vagus nerve is composed primarily of nonmyelinated sensory neurons whose cell bodies are located in the nodose ganglion (NG). The vagus has widespread projections that supply most visceral organs, including the bladder. Because of its nonspinal route, the vagus nerve itself is not directly damaged from spinal cord injury (SCI). Because most viscera, including bladder, are dually innervated by spinal and vagal sensory neurons, an impact of SCI on the sensory component of vagal circuitry may contribute to post-SCI visceral pathologies. To determine whether SCI, in male Wistar rats, might impact neurochemical characteristics of NG neurons, immunohistochemical assessments were performed for P2X3 receptor expression, isolectin B4 (IB4) binding, and substance P expression, three known injury-responsive markers in sensory neuronal subpopulations. In addition to examining the overall population of NG neurons, those innervating the urinary bladder also were assessed separately. All three of the molecular markers were represented in the NG from noninjured animals, with the majority of the neurons binding IB4. In the chronically injured rats, there was a significant increase in the number of NG neurons expressing P2X3 and a significant decrease in the number binding IB4 compared with noninjured animals, a finding that held true also for the bladder-innervating population. Overall, these results indicate that vagal afferents, including those innervating the bladder, display neurochemical plasticity post-SCI that may have implications for visceral homeostatic mechanisms and nociceptive signaling.
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Registered trials
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