ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Central 5-HT neurotransmission modulates weight loss following gastric bypass surgery in obese individuals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Brain Serotonin Transporter Is Elevated in Obesity: Bayesian and Frequentist Meta-Analyses.Diabetes, obesity & metabolism · 2026Pooled it
- Effects of bariatric surgery and dietary interventions for obesity on brain neurotransmitter systems and metabolism: A systematic review of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Pooled it
- Central noradrenaline transporter availability in highly obese, non-depressed individuals.European journal of nuclear medicine and molecular imaging · 2017Trial
- Effects of psilocybin on body weight, body composition, and metabolites in male and female mice.Physiology & behavior · 2024Article
- 5-Methoxy-2-aminoindane Reverses Diet-Induced Obesity and Improves Metabolic Parameters in Mice: A Potential New Class of Antiobesity Therapeutics.ACS pharmacology & translational science · 2024Article
- Article
- Sexual health and serotonin 4 receptor brain binding in unmedicated patients with depression-a NeuroPharm study.Translational psychiatry · 2023Article
- Central Serotonin/Noradrenaline Transporter Availability and Treatment Success in Patients with Obesity.Brain sciences · 2022Article
- Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice.Translational psychiatry · 2022Article
- Gut-brain mechanisms underlying changes in disordered eating behaviour after bariatric surgery: a review.Reviews in endocrine & metabolic disorders · 2022Review
- Serotonin transporter is negatively associated with body mass index after glucose loading in humans.Brain imaging and behavior · 2022Article
- Chronic Intestinal Pseudo-Obstruction: Is There a Connection with Gut Microbiota?Microorganisms · 2021Review
- Central Noradrenergic Neurotransmission and Weight Loss 6 Months After Gastric Bypass Surgery in Patients with Severe Obesity.Obesity surgery · 2021Article
- The Role of Positron Emission Tomography in Bariatric Surgery Research: a Review.Obesity surgery · 2021Review
- Polymorphism of the Serotonin Transporter Gene and the Peripheral 5-Hydroxytryptamine in Obstructive Sleep Apnea: What Do We Know and What are We Looking for? A Systematic Review of the Literature.Nature and science of sleep · 2021Review
- Common HTR2A variants and 5-HTTLPR are not associated with human in vivo serotonin 2A receptor levels.Human brain mapping · 2020Article
- Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study.Human brain mapping · 2019Article
- Noradrenaline transporter availability on [European journal of nuclear medicine and molecular imaging · 2018Article
- The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters.Scientific reports · 2018Article
- Negative Association Between Allopregnanolone and Cerebral Serotonin Transporter Binding in Healthy Women of Fertile Age.Frontiers in psychology · 2018Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebral serotonin (5-HT) system shows distinct differences in obesity compared with the lean state. Here, it was investigated whether serotonergic neurotransmission in obesity is a stable trait or changes in association with weight loss induced by Roux-in-Y gastric bypass (RYGB) surgery. In vivo cerebral 5-HT2A receptor and 5-HT transporter binding was determined by positron emission tomography in 21 obese [four men; body mass index (BMI), 40.1 ± 4.1 kg/m(2)] and 10 lean (three men; BMI, 24.6 ± 1.5 kg/m(2)) individuals. Fourteen obese individuals were re-examined after RYGB surgery. First, it was confirmed that obese individuals have higher cerebral 5-HT2A receptor binding than lean individuals. Importantly, we found that higher presurgical 5-HT2A receptor binding predicted greater weight loss after RYGB and that the change in 5-HT2A receptor and 5-HT transporter binding correlated with weight loss after RYGB. The changes in the 5-HT neurotransmission before and after RYGB are in accordance with a model wherein the cerebral extracellular 5-HT level modulates the regulation of body weight. Our findings support that the cerebral 5-HT system contributes both to establish the obese condition and to regulate the body weight in response to RYGB.
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