ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Idiosyncratic brain activation patterns are associated with poor social comprehension in autism.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.
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Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Naturalistic stimuli in neuroimaging studies of autism spectrum disorder: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Brain correlates of declarative memory atypicalities in autism: a systematic review of functional neuroimaging findings.Molecular autism · 2023Pooled it
- Temporally-resolved deep learning reveals autism symptom-specific neural signatures during naturalistic social experiences.Research square · 2026Article
- Brain idiosyncrasy during biological-motion perception is amplified in autistic individuals with intellectual impairment.Journal of neurodevelopmental disorders · 2026Article
- Pregistered movie-fMRI analyses reveal altered visual feature encoding in autism in pSTS.bioRxiv : the preprint server for biology · 2026Article
- Individuals with Intermittent Explosive Disorder Exhibit Idiosyncratic Neural Responses during Social-emotional Processing.bioRxiv : the preprint server for biology · 2026Article
- Unique Amygdala Signatures and Shared Prefrontal Deficits in Autism: Mapping Social Heterogeneity via Naturalistic functional Magnetic Resonance Imaging.bioRxiv : the preprint server for biology · 2026Article
- Reduced inter-subject functional connectivity during movies in autism: replicability across cross-national fMRI datasets.Molecular autism · 2026Article
- Detection of Idiosyncratic Gaze-Fingerprint Signatures in Humans.Psychological science · 2026Article
- Modeling gaze behavior with continuous-time markov chains to investigate social attention dynamics in autism.Scientific reports · 2025Article
- Structured Neural Variability from Repeated Naturalistic Video Watching Experiences.bioRxiv : the preprint server for biology · 2025Article
- Social inference brain networks in autistic adults during movie-viewing: functional specialization and heterogeneity.Molecular autism · 2025Article
- Neural similarity and interaction success in autistic and non-autistic adolescents.Scientific reports · 2025Article
- Altered interactive dynamics of gaze behavior during face-to-face interaction in autistic individuals: a dual eye-tracking study.Molecular autism · 2025Article
- Stimulus Selection Influences Prediction of Individual Phenotypes in Naturalistic Conditions.Human brain mapping · 2025Article
- Real-world goal-directed behavior reveals aberrant functional brain connectivity in children with ADHD.PloS one · 2025Article
- Altered neural response to social awkwardness in schizophrenia spectrum disorders.Social cognitive and affective neuroscience · 2024Article
- Idiosyncratic pupil regulation in autistic children.Autism research : official journal of the International Society for Autism Research · 2024Article
- Evidence for the role of affective theory of mind in face-name associative memory.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2024Article
- Will you read how I will read? Naturalistic fMRI predictors of emergent reading.Neuropsychologia · 2024Article
23 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Autism spectrum disorder (ASD) features profound social deficits but neuroimaging studies have failed to find any consistent neural signature. Here we connect these two facts by showing that idiosyncratic patterns of brain activation are associated with social comprehension deficits. Human participants with ASD (N = 17) and controls (N = 20) freely watched a television situation comedy (sitcom) depicting seminaturalistic social interactions ("The Office", NBC Universal) in the scanner. Intersubject correlations in the pattern of evoked brain activation were reduced in the ASD group-but this effect was driven entirely by five ASD subjects whose idiosyncratic responses were also internally unreliable. The idiosyncrasy of these five ASD subjects was not explained by detailed neuropsychological profile, eye movements, or data quality; however, they were specifically impaired in understanding the social motivations of characters in the sitcom. Brain activation patterns in the remaining ASD subjects were indistinguishable from those of control subjects using multiple multivariate approaches. Our findings link neurofunctional abnormalities evoked by seminaturalistic stimuli with a specific impairment in social comprehension, and highlight the need to conceive of ASD as a heterogeneous classification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.