ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Mapping synapses by conjugate light-electron array tomography.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- Data-driven synapse classification reveals a logic of glutamate receptor diversity.bioRxiv : the preprint server for biology · 2025Article
- Morphomics via next-generation electron microscopy.Journal of molecular cell biology · 2024Review
- Array tomography: trails to discovery.Methods in microscopy · 2024Article
- Unambiguous identification of asymmetric and symmetric synapses using volume electron microscopy.Frontiers in neuroanatomy · 2024Article
- Developing a Toolbox of Antibodies Validated for Array Tomography-Based Imaging of Brain Synapses.eNeuro · 2023Article
- Developing a Toolbox of Antibodies Validated for Array Tomography-Based Imaging of Brain Synapses.bioRxiv : the preprint server for biology · 2023Article
- Bringing synapses into focus: Recent advances in synaptic imaging and mass-spectrometry for studying synaptopathy.Frontiers in synaptic neuroscience · 2023Review
- Array tomography: 15 years of synaptic analysis.Neuronal signaling · 2022Article
- A scalable and modular automated pipeline for stitching of large electron microscopy datasets.eLife · 2022Article
- Volume electron microscopy.Nature reviews. Methods primers · 2022Article
- Editorial: Quantifying and controlling the nano-architecture of neuronal synapses.Frontiers in synaptic neuroscience · 2022Article
- A versatile enhanced freeze-substitution protocol for volume electron microscopy.Frontiers in cell and developmental biology · 2022Article
- Imaging Synaptic Density: The Next Holy Grail of Neuroscience?Frontiers in neuroscience · 2022Review
- Correlative Organelle Microscopy: Fluorescence Guided Volume Electron Microscopy of Intracellular Processes.Frontiers in cell and developmental biology · 2022Article
- Extensive Structural Remodeling of the Axonal Arbors of Parvalbumin Basket Cells during Development in Mouse Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Gephyrin-Lacking PV Synapses on Neocortical Pyramidal Neurons.International journal of molecular sciences · 2021Article
- Unique properties of dually innervated dendritic spines in pyramidal neurons of the somatosensory cortex uncovered by 3D correlative light and electron microscopy.PLoS biology · 2021Article
- A workflow for streamlined acquisition and correlation of serial regions of interest in array tomography.BMC biology · 2021Article
- Conduction Velocity Along the Local Axons of Parvalbumin Interneurons Correlates With the Degree of Axonal Myelination.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Permeabilization-freeeLife · 2021Article
5 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
Abstract
Synapses of the mammalian CNS are diverse in size, structure, molecular composition, and function. Synapses in their myriad variations are fundamental to neural circuit development, homeostasis, plasticity, and memory storage. Unfortunately, quantitative analysis and mapping of the brain's heterogeneous synapse populations has been limited by the lack of adequate single-synapse measurement methods. Electron microscopy (EM) is the definitive means to recognize and measure individual synaptic contacts, but EM has only limited abilities to measure the molecular composition of synapses. This report describes conjugate array tomography (AT), a volumetric imaging method that integrates immunofluorescence and EM imaging modalities in voxel-conjugate fashion. We illustrate the use of conjugate AT to advance the proteometric measurement of EM-validated single-synapse analysis in a study of mouse cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.