ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
DSCAM promotes refinement in the mouse retina through cell death and restriction of exploring dendrites.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 54 citations in OpenAlex.
- Future Directions for Studying the Potential of Mammalian Dscam in Autism Spectrum Disorder and Alzheimer's Disease: Insights from Dose Sensitivity.Molecular neurobiology · 2025Review
- Prevalence and diversity of retinal disease in adults with Down syndrome.Eye (London, England) · 2025Review
- Exploring perspectives of Dscam for cognitive deficits: a review of multifunction for regulating neural wiring in homeostasis.Frontiers in molecular neuroscience · 2025Review
- Cognitive behavioral phenotyping of DSCAM heterozygosity as a model for autism spectrum disorder.Genes, brain, and behavior · 2024Article
- Synaptic cell adhesion molecules contribute to the pathogenesis and progression of fragile X syndrome.Frontiers in cellular neuroscience · 2024Review
- The rod synapse in aging wildtype and Dscaml1 mutant mice.PloS one · 2023Article
- Activation of oxytocin receptors in mouse GABAergic amacrine cells modulates retinal dopaminergic signaling.BMC biology · 2022Article
- DSCAM is differentially patterned along the optic axon pathway in the developing Xenopus visual system and guides axon termination at the target.Neural development · 2022Article
- Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice.Molecular psychiatry · 2021Article
- Structure of cell-cell adhesion mediated by the Down syndrome cell adhesion molecule.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Role of DSCAM in the Development of Neural Control of Movement and Locomotion.International journal of molecular sciences · 2021Review
- The γ-Protocadherins Regulate the Survival of GABAergic Interneurons during Developmental Cell Death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Signalling Pathways Implicated in Alzheimer's Disease Neurodegeneration in Individuals with and without Down Syndrome.International journal of molecular sciences · 2020Review
- LKB1 coordinates neurite remodeling to drive synapse layer emergence in the outer retina.eLife · 2020Article
- Structure and Functions of Sidekicks.Frontiers in molecular neuroscience · 2020Review
- Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation.The EMBO journal · 2019Article
- Zebrafish expression reporters and mutants reveal that the IgSF cell adhesion molecule Dscamb is required for feeding and survival.Journal of neurogenetics · 2018Article
- Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death.Cell death & disease · 2018Article
- DSCAM promotes self-avoidance in the developing mouse retina by masking the functions of cadherin superfamily members.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring.Neural development · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
In this study we develop and use a gain-of-function mouse allele of the Down syndrome cell adhesion molecule (Dscam) to complement loss-of-function models. We assay the role of Dscam in promoting cell death, spacing, and laminar targeting of neurons in the developing mouse retina. We find that ectopic or overexpression of Dscam is sufficient to drive cell death. Gain-of-function studies indicate that Dscam is not sufficient to increase spatial organization, prevent cell-to-cell pairing, or promote active avoidance in the mouse retina, despite the similarity of the Dscam loss-of-function phenotype in the mouse retina to phenotypes observed in Drosophila Dscam1 mutants. Both gain- and loss-of-function studies support a role for Dscam in targeting neurites; DSCAM is necessary for precise dendrite lamination, and is sufficient to retarget neurites of outer retinal cells after ectopic expression. We further demonstrate that DSCAM guides dendrite targeting in type 2 dopaminergic amacrine cells, by restricting the stratum in which exploring retinal dendrites stabilize, in a Dscam dosage-dependent manner. Based on these results we propose a single model to account for the numerous Dscam gain- and loss-of-function phenotypes reported in the mouse retina whereby DSCAM eliminates inappropriately placed cells and connections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.