ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Emergence of rich-club topology and coordinated dynamics in development of hippocampal functional networks in vitro.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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76 citing papers in PubMed.
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- Neural network embedding of functional microconnectome.Network neuroscience (Cambridge, Mass.) · 2025Article
- Disruption of global brain network topology in amnestic MCI: evidence from multimodal DTI and fMRI.Frontiers in neuroscience · 2025Article
- MEA-NAP: A flexible network analysis pipeline for neuronal 2D and 3D organoid multielectrode recordings.Cell reports methods · 2024Article
- MEA-NAP compares microscale functional connectivity, topology, and network dynamics in organoid or monolayer neuronal cultures.bioRxiv : the preprint server for biology · 2024Article
- Ensemble learning and ground-truth validation of synaptic connectivity inferred from spike trains.PLoS computational biology · 2024Article
- Cortical timescales and the modular organization of structural and functional brain networks.Human brain mapping · 2024Article
- Response inhibition in premotor cortex corresponds to a complex reshuffle of the mesoscopic information network.Network neuroscience (Cambridge, Mass.) · 2024Article
- The neuropeptidergic connectome of C. elegans.Neuron · 2023Article
16 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
Recent studies demonstrated that the anatomical network of the human brain shows a "rich-club" organization. This complex topological feature implies that highly connected regions, hubs of the large-scale brain network, are more densely interconnected with each other than expected by chance. Rich-club nodes were traversed by a majority of short paths between peripheral regions, underlining their potential importance for efficient global exchange of information between functionally specialized areas of the brain. Network hubs have also been described at the microscale of brain connectivity (so-called "hub neurons"). Their role in shaping synchronous dynamics and forming microcircuit wiring during development, however, is not yet fully understood. The present study aimed to investigate the role of hubs during network development, using multi-electrode arrays and functional connectivity analysis during spontaneous multi-unit activity (MUA) of dissociated primary mouse hippocampal neurons. Over the first 4 weeks in vitro, functional connectivity significantly increased in strength, density, and size, with mature networks demonstrating a robust modular and small-world topology. As expected by a "rich-get-richer" growth rule of network evolution, MUA graphs were found to form rich-clubs at an early stage in development (14 DIV). Later on, rich-club nodes were a consistent topological feature of MUA graphs, demonstrating high nodal strength, efficiency, and centrality. Rich-club nodes were also found to be crucial for MUA dynamics. They often served as broker of spontaneous activity flow, confirming that hub nodes and rich-clubs may play an important role in coordinating functional dynamics at the microcircuit level.
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