Evidence map›Paper›PMID 25855047›Full record

Observational studyAIDS and behavior2015

Prediction of HIV Virologic Failure Among Adolescents Using the Pediatric Symptom Checklist.

Elizabeth D Lowenthal, Tafireyi Marukutira, Ontibile Tshume, Jennifer Chapman, Gabriel M Anabwani, Robert Gross

Abstract readObservational Study
In one paragraph

Observational study in AIDS and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Trends in HIV Treatment Adherence Before and After HIV Status Disclosure to Adolescents in Botswana.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2020
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Elizabeth D LowenthalDepartments of Pediatrics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. lowenthale@email.chop.edu.
Tafireyi MarukutiraBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Ontibile TshumeBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Jennifer ChapmanChildren's Hospital of Philadelphia, 3535 Market Street, Room 1513, Philadelphia, 19104, PA, USA.
Gabriel M AnabwaniBotswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
Robert GrossDepartments of Medicine (Infectious Diseases) and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Botswana-Baylor Children's Clinical Center of Excellence · BWChildren's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI VINCENT LO RE · 1999 to 2026
$78.6M
Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Knashawn Hodge Morales · 2013 to 2026
$23.5M
Targeted Monitoring and Determinants of Adherence in Adolescents with HIVK23MH095669 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI LOWENTHAL, ELIZABETH DAWN · 2012 to 2016
$874k
NIAID NIH HHS P30 AI045008NIMH NIH HHS K23 MH095669NIMH NIH HHS P30 MH097488PEPFARPHS HHS P30 A1 045008
6 · The paper itself

Abstract

Psychosocial dysfunction is a risk factor for treatment non-adherence among children and adolescents. A previous study showed that high scores on the Pediatric Symptom Checklist (PSC) were associated with a history of HIV virologic failure. We assessed whether high scores on the PSC could predict virologic failure in HIV-infected youth. Caregivers of 234 adolescents between the ages of 10 and 16 years were asked to complete a PSC at baseline. Elevated PSC scores were associated with virologic failure in the subsequent 6 months. PSC scores may help guide resource utilization when viral load monitoring is limited.

Indexed as

AdolescentAnti-HIV AgentsBotswanaChecklistChildFemaleHIV InfectionsHumansMaleMass ScreeningPediatricsPredictive Value of TestsProspective StudiesRisk FactorsSurveys and QuestionnairesTreatment FailureAnti-HIV AgentsAdolescentsHIVPediatric Symptom ChecklistPsychosocial dysfunctionVirologic failure

Identifiers

PMID25855047
PMCPMC4600009
OpenAlexW2053792323

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.