Evidence map›Paper›PMID 25854987›Full record

SynthesisHypertension research : official journal of the Japanese Society of Hypertension2015

The impact of angiotensin receptor blockers on arterial stiffness: a meta-analysis.

Feng Peng, Hongming Pan, Bin Wang, Jinxiu Lin, Wenquan Niu

Open access · bronzeAbstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Hypertension research : official journal of the Japanese Society of Hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Arterial stiffness and hypertension.Clinical hypertension · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Cardiovascular calcification and subcortical bone demineralization in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2017
    Article
  15. Association of worsening arterial stiffness with incident heart failure in asymptomatic patients with cardiovascular risk factors.Hypertension research : official journal of the Japanese Society of Hypertension · 2017
    Article
  16. Oscillometric assessment of arterial stiffness in everyday clinical practice.Hypertension research : official journal of the Japanese Society of Hypertension · 2017
    Article
  17. Article
  18. Antihypertensive drugs and statins must be considered in arterial stiffness evaluation in patients with Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Feng PengDepartment of Cardiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Hongming PanBasic Medical Science College, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Bin WangBasic Medical Science College, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Jinxiu LinDepartment of Cardiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Wenquan NiuState Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fujian Medical University · CNQiqihar Medical University · CNRuijin Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some studies reported a protective role of angiotensin receptor blockers (ARBs) against arterial stiffness. Therefore, we performed a meta-analysis of published clinical trials to systematically assess the impact of ARBs on arterial stiffness as measured by using pulse wave velocity (PWV). Eligible articles were identified by searching PubMed, EMBASE, Cochrane, Wanfang and CNKI databanks before 31 July 2014. The data were extracted independently and in duplicate. Forty articles including 53 clinical trials qualified, including 1650 and 1659 subjects in ARB treatment and control groups, respectively. Overall reductions in carotid-femoral PWV (cfPWV) and brachial-ankle PWV (baPWV) were statistically significant, with an average of -42.52 cm s(-1) (95% CI: -81.82 to -3.21; P=0.034) and -107.08 cm s(-1) (95% CI: -133.98 to -80.18; P<0.0005), respectively, after receiving ARBs. Subgroup analysis by ARB type revealed that telmisartan (weighted mean difference or WMD=-100.82 cm s(-1); P<0.0005) and valsartan (WMD=-104.59 cm s(-1); P<0.0005) significantly reduced baPWV, but only valsartan reduced cfPWV (WMD=-65.58; P=0.030). cfPWV was significantly reduced in comparisons of ARBs with placebo (WMD=-79.65 cm s(-1); P=0.001), and baPWV was significantly reduced with calcium channel blockers (WMD=-130.74 cm s(-1); P<0.0005). There were low probabilities of publication bias. Taken together, our findings support the important role of ARB treatment in improving arterial stiffness.

Indexed as

Angiotensin II Type 1 Receptor BlockersAngiotensin Receptor AntagonistsAnkle Brachial IndexHemodynamicsHumansHypertensionPulse Wave AnalysisVascular StiffnessAngiotensin II Type 1 Receptor BlockersAngiotensin Receptor Antagonists

Identifiers

PMID25854987
OpenAlexW2015585990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.