ArticleJournal of Alzheimer's disease : JAD2015
Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment.
Article in Journal of Alzheimer's disease : JAD, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid.Alzheimer's research & therapy · 2026Article
- Predicting apathy using connectome-based models derived from static and dynamic brain connectivity.Social cognitive and affective neuroscience · 2026Article
- A Cross Sectional and Longitudinal Assessment of Neuropsychiatric Symptoms and Brain Functional Connectivity in Patients With Mild Cognitive Impairment, Cerebrovascular Disease and Parkinson Disease.International journal of geriatric psychiatry · 2025Article
- Accelerated aging in people living with HIV: The neuroimmune feedback model.Brain, behavior, & immunity - health · 2024Article
- Functional connectivity and mild behavioral impairment in dementia-free elderly.Alzheimer's & dementia (New York, N. Y.) · 2023Article
- A transdiagnostic review of neuroimaging studies of apathy and disinhibition in dementia.Brain : a journal of neurology · 2022Review
- Negative affective burden is associated with higher resting-state functional connectivity in subjective cognitive decline.Scientific reports · 2022Article
- Amyloid-β oligomers in the nucleus accumbens decrease motivation via insertion of calcium-permeable AMPA receptors.Molecular psychiatry · 2022Article
- Neural correlates of repetitive negative thinking: Dimensional evidence across the psychopathological continuum.Frontiers in psychiatry · 2022Article
- Affective symptoms and regional cerebral tau burden in early-stage Alzheimer's disease.International journal of geriatric psychiatry · 2021Article
- Insights into the Pathophysiology of Psychiatric Symptoms in Central Nervous System Disorders: Implications for Early and Differential Diagnosis.International journal of molecular sciences · 2021Review
- Acupressure and Cognitive Training Can Improve Cognitive Functions of Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial.Frontiers in psychology · 2021Article
- Resting-State Functional Connectivity Signatures of Apathy in Community-Living Older Adults.Frontiers in aging neuroscience · 2021Article
- Revisiting Apathy in Alzheimer's Disease: From Conceptualization to Therapeutic Approaches.Behavioural neurology · 2021Review
- Neural Correlates of Mild Behavioral Impairment: A Functional Brain Connectivity Study Using Resting-State Functional Magnetic Resonance Imaging.Journal of Alzheimer's disease : JAD · 2021Article
- Aberrant Topological Patterns of Structural Covariance Networks in Cognitively Normal Elderly Adults With Mild Behavioral Impairment.Frontiers in neuroanatomy · 2021Article
- Dissociable Functional Brain Networks Associated With Apathy in Subcortical Ischemic Vascular Disease and Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- Resting-state fMRI analysis in apathetic Alzheimer's disease.Diagnostic and interventional radiology (Ankara, Turkey) · 2020Article
- Functional Connectivity Changes Across the Spectrum of Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment and Alzheimer's Disease.Frontiers in neuroinformatics · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNeuropsychiatric symptoms (NPS), such as apathy and depression, commonly accompany cognitive and functional decline in early Alzheimer's disease (AD). Prior studies have shown associations between affective NPS and neurodegeneration of medial frontal and inferior temporal regions in mild cognitive impairment (MCI) and AD dementia.
objectiveTo investigate the association between functional connectivity in four brain networks and NPS in elderly with MCI.
methodsNPS were assessed using the Neuropsychiatric Inventory in 42 subjects with MCI. Resting-state functional connectivity in four networks (default mode network, fronto-parietal control network (FPCN), dorsal attention network, and ventral attention network) was assessed using seed-based magnetic resonance imaging. Factor analysis was used to identify two factors of NPS: Affective and Hyperactivity. Linear regression models were utilized with the neuropsychiatric factors as the dependent variable and the four networks as the predictors of interest. Covariates included age, gender, premorbid intelligence, processing speed, memory, head movement, and signal-to-noise ratio. These analyses were repeated with the individual items of the affective factor, using the same predictors.
resultsThere was a significant association between greater Affective factor symptoms and reduced FPCN connectivity (p = 0.03). There was no association between the Hyperactivity factor and any of the networks. Secondary analyses revealed an association between greater apathy and reduced FPCN connectivity (p = 0.005), but none in other networks.
conclusionsDecreased connectivity in the FPCN may be associated with greater affective symptoms, particularly apathy, early in AD. These findings extend prior studies, using different functional imaging modalities in individuals with greater disease severity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.