SynthesisNutrients2015
Meta-analysis of the association between vitamin D and autoimmune thyroid disease.
Synthesis in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 13 syntheses or guidelines pooled it, 226 citations in OpenAlex.
- Serum 25-hydroxyvitamin D levels are associated with thyroid diseases: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Are there prophylactic effects of vitamin D among healthier adult patients? A systematic review of randomized controlled trials.BMC nutrition · 2025Pooled it
- Pooled it
- Association between serum vitamin D level and Graves' disease: a systematic review and meta-analysis.Nutrition journal · 2024Pooled it
- Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis.Frontiers in endocrinology · 2024Pooled it
- The Influence of Nutritional Intervention in the Treatment of Hashimoto's Thyroiditis-A Systematic Review.Nutrients · 2023Pooled it
- Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Effects of vitamin D treatment on thyroid function and autoimmunity markers in patients with Hashimoto's thyroiditis-A meta-analysis of randomized controlled trials.Journal of clinical pharmacy and therapeutics · 2022Pooled it
- Serum 25-hydoxyvitamin D concentrations in relation to Hashimoto's thyroiditis: a systematic review, meta-analysis and meta-regression of observational studies.European journal of nutrition · 2020Pooled it
- Association between vitamin D deficiency and risk of thyroid cancer: a case-control study and a meta-analysis.Journal of endocrinological investigation · 2018Pooled it
- Pooled it
- Vitamin D receptor gene FokI but not TaqI, ApaI, BsmI polymorphism is associated with Hashimoto's thyroiditis: a meta-analysis.Scientific reports · 2017Pooled it
- Vitamin D and Graves' disease: a meta-analysis update.Nutrients · 2015Pooled it
- Association of Vitamin D Levels and Systemic Inflammation in Patients with Hashimoto's Thyroiditis.Diseases (Basel, Switzerland) · 2026Article
- The role of nutrition on thyroid health and disease: myths and facts.Journal of endocrinological investigation · 2026Review
- Influence of Vitamin E Intake on Sexual Function and Depressive Symptoms in Young Women with Euthyroid Autoimmune Thyroiditis Undergoing Vitamin D Therapy: A Pilot Study.International journal of molecular sciences · 2026Article
- Effect of Prenatal Vitamin D and Selenium Supplementation on Minipuberty in Male Offspring of Women with Autoimmune Thyroiditis.Nutrients · 2026Article
- Impact of Maternal Euthyroid Autoimmune Thyroiditis on Minipuberty in Female Offspring.Nutrients · 2026Article
- Vitamin D receptor (ApaI/BsmI) polymorphisms, human leukocyte antigen-DQB2/DRB3 sub-alleles, and endoplasmic reticulum stress: unravelling their interplay in the pathogenesis of Graves' disease in a tertiary care centre.Molecular biology reports · 2026Article
- Risk of Functional Disorders and/or Thyroid Autoimmunity and Its Association with 25OH Vitamin D and Magnesium Levels: A Population-Based Case-Control Study.Medical sciences (Basel, Switzerland) · 2026Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although emerging evidence suggests that low levels of vitamin D may contribute to the development of autoimmune disease, the relationship between vitamin D reduction and autoimmune thyroid disease (AITD), which includes Graves' disease (GD) and Hashimoto thyroiditis (HT), is still controversial. The aim was to evaluate the association between vitamin D levels and AITD through systematic literature review. We identified all studies that assessed the association between vitamin D and AITD from PubMed, Embase, CENTRAL, and China National Knowledge Infrastructure (CNKI) databases. We included studies that compared vitamin D levels between AITD cases and controls as well as those that measured the odds of vitamin D deficiency by AITD status. We combined the standardized mean differences (SMD) or the odds ratios (OR) in a random effects model. Twenty case-control studies provided data for a quantitative meta-analysis. Compared to controls, AITD patients had lower levels of 25(OH)D (SMD: -0.99, 95% CI: -1.31, -0.66) and were more likely to be deficient in 25(OH)D (OR 2.99, 95% CI: 1.88, 4.74). Furthermore, subgroup analyses result showed that GD and HT patients also had lower 25(OH)D levels and were more likely to have a 25(OH)D deficiency, suggesting that low levels of serum 25(OH)D was related to AITD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.