Evidence map›Paper›PMID 25854674›Full record

ArticleEuropean journal of psychotraumatology2015

Restoring large-scale brain networks in PTSD and related disorders: a proposal for neuroscientifically-informed treatment interventions.

Ruth A Lanius, Paul A Frewen, Mischa Tursich, Rakesh Jetly, Margaret C McKinnon

3 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of psychotraumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 131 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04251624 naunknown statusnot on this mapstarted 2019, after this paper: background citation

A Randomized Control Trial Examining the Treatment Efficacy of a Novel Approach to Cognitive Remediation in Public Safety Personnel With Post-traumatic Stress Disorder (PTSD) and Co-morbid Conditions

TypeinterventionalSponsorHomewood Research InstituteRan2019 to 2025Enrolled88ConditionsPost Traumatic Stress Disorder, Cognitive DeficitArmsGoal Management Therapy, Psychosocial Education
NCT04457271 nawithdrawnnot on this mapstarted 2023, after this paper: background citation

An EffectivenessTrial Examining a Novel Approach to Cognitive Remediation in Individuals With Post-Traumatic Stress Disorder (PTSD)

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2023 to 2024Enrolled0ConditionsPTSD, Post-traumatic Stress Disorder, Cognitive Impairment, Cognitive DysfunctionArmsGoal Management Training (GMT)
NCT06035809 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Effects of Sensory Motor Arousal Regulation Treatment (SMART) on Adults With PTSD

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2026 to 2028Enrolled80ConditionsPTSD, Post-traumatic Stress DisorderArmsSMART
3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruth A LaniusWestern University, London, ON, Canada.
Paul A FrewenWestern University, London, ON, Canada.
Mischa TursichWestern University, London, ON, Canada.
Rakesh JetlyCanadian Forces, Health Services, Ottawa, Ontario, Canada.
Margaret C McKinnonMcMaster University, Hamilton, Hamilton, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThree intrinsic connectivity networks in the brain, namely the central executive, salience, and default mode networks, have been identified as crucial to the understanding of higher cognitive functioning, and the functioning of these networks has been suggested to be impaired in psychopathology, including posttraumatic stress disorder (PTSD).

objective1) To describe three main large-scale networks of the human brain; 2) to discuss the functioning of these neural networks in PTSD and related symptoms; and 3) to offer hypotheses for neuroscientifically-informed interventions based on treating the abnormalities observed in these neural networks in PTSD and related disorders.

methodsLiterature relevant to this commentary was reviewed.

resultsIncreasing evidence for altered functioning of the central executive, salience, and default mode networks in PTSD has been demonstrated. We suggest that each network is associated with specific clinical symptoms observed in PTSD, including cognitive dysfunction (central executive network), increased and decreased arousal/interoception (salience network), and an altered sense of self (default mode network). Specific testable neuroscientifically-informed treatments aimed to restore each of these neural networks and related clinical dysfunction are proposed.

conclusionsNeuroscientifically-informed treatment interventions will be essential to future research agendas aimed at targeting specific PTSD and related symptoms.

Indexed as

central executive networkdefault mode networkdissociationinsulainteroceptionIntrinsic networksmindfulnessneurofeedbackPTSDsalience network

Identifiers

PMID25854674
PMCPMC4390556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.