ArticleNature communications2015
Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 64 citations in OpenAlex.
- A pivot-tether model for nucleosome recognition by the chromosomal passenger complex.EMBO reports · 2025Article
- The landscape in telomere related gene prognostic signature for survival and medication treatment effectiveness prediction in hepatocellular carcinoma.Discover oncology · 2024Article
- Cyclin A/Cdk1 promotes chromosome alignment and timely mitotic progression.Molecular biology of the cell · 2024Article
- Advancing Cancer Therapy: The Role of KIF20A as a Target for Inhibitor Development and Immunotherapy.Cancers · 2024Review
- Cyclin A/Cdk1 promotes chromosome alignment and timely mitotic progression.bioRxiv : the preprint server for biology · 2023Article
- Non-canonical MLL1 activity regulates centromeric phase separation and genome stability.Nature cell biology · 2023Article
- CDCA8 promotes bladder cancer survival by stabilizing HIF1α expression under hypoxia.Cell death & disease · 2023Article
- Mechanistic basis for Sgo1-mediated centromere localization and function of the CPC.The Journal of cell biology · 2022Article
- Genetic analysis of Caenorhabditis elegans Haspin-like genes shows that hasp-1 plays multiple roles in the germline.Biology open · 2022Article
- Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins.Journal of molecular biology · 2022Article
- The phospho-docking protein 14-3-3 regulates microtubule-associated proteins in oocytes including the chromosomal passenger Borealin.PLoS genetics · 2022Article
- C9ORF78 partially localizes to centromeres and plays a role in chromosome segregation.Experimental cell research · 2022Article
- Borealin Promotes Tumor Growth and Metastasis by Activating the Wnt/β-Catenin Signaling Pathway in Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2022Article
- Distinct roles of haspin in stem cell division and male gametogenesis.Scientific reports · 2021Article
- A degron-based strategy reveals new insights into Aurora B function in C. elegans.PLoS genetics · 2021Article
- APC/CJournal of cell science · 2020Article
- The Borealin dimerization domain interacts with Sgo1 to drive Aurora B-mediated spindle assembly.Molecular biology of the cell · 2020Article
- The right place at the right time: Aurora B kinase localization to centromeres and kinetochores.Essays in biochemistry · 2020Review
- Establishing correct kinetochore-microtubule attachments in mitosis and meiosis.Essays in biochemistry · 2020Review
- Functional Analysis of the Plant Chromosomal Passenger Complex.Plant physiology · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The chromosomal passenger complex (CPC) localizes to centromeres where it activates the mitotic checkpoint in response to inappropriate inter-kinetochore tension. This error correction function is essential for proper chromosome segregation. Here we define several critical features of CPC localization and function. First, the Borealin dimerization domain suppresses dynamic exchange at the centromere to allow optimal CPC function. Second, Borealin dimerization is essential to target a subpopulation of CPC proximal to the kinetochore when the mitotic spindle is disrupted. This subpopulation is also needed for full CPC checkpoint function. The existence of a pool of CPC at the kinetochore suggests that error correction is more complicated than predicted from the Aurora B phosphorylation gradient model. Finally, Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin pool, while Aurora B and Mps1 play minimal roles in maintaining CPC localization once cells are in mitosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.