Evidence map›Paper›PMID 25854485›Full record

ArticleJournal of clinical microbiology2015

PhyResSE: a Web Tool Delineating Mycobacterium tuberculosis Antibiotic Resistance and Lineage from Whole-Genome Sequencing Data.

Silke Feuerriegel, Viola Schleusener, Patrick Beckert, Thomas A Kohl, Paolo Miotto, Daniela M Cirillo, Andrea M Cabibbe, Stefan Niemann, Kurt Fellenberg

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Open-access genomic drug resistance prediction tools forJournal of clinical microbiology · 2026
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
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  7. Article
  8. Genomic landscape ofNew microbes and new infections · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Prediction of antimicrobial resistance inMicrobiology spectrum · 2025
    Article
  14. Evaluation of the role ofMicrobiology spectrum · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Journal of clinical tuberculosis and other mycobacterial diseases · 2024
    Article

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Silke FeuerriegelMolecular Mycobacteriology, Research Center Borstel, Borstel, Germany German Center for Infection Research (DZIF), Borstel Site, Borstel, Germany.
Viola SchleusenerBioinformatics, Research Center Borstel, Borstel, Germany.
Patrick BeckertMolecular Mycobacteriology, Research Center Borstel, Borstel, Germany German Center for Infection Research (DZIF), Borstel Site, Borstel, Germany.
Thomas A KohlMolecular Mycobacteriology, Research Center Borstel, Borstel, Germany.
Paolo MiottoEmerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Daniela M CirilloEmerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Andrea M CabibbeEmerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Stefan NiemannMolecular Mycobacteriology, Research Center Borstel, Borstel, Germany German Center for Infection Research (DZIF), Borstel Site, Borstel, Germany sniemann@fz-borstel.de kfellenberg@fz-borstel.de.
Kurt FellenbergBioinformatics, Research Center Borstel, Borstel, Germany sniemann@fz-borstel.de kfellenberg@fz-borstel.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic-resistant tuberculosis poses a global threat, causing the deaths of hundreds of thousands of people annually. While whole-genome sequencing (WGS), with its unprecedented level of detail, promises to play an increasingly important role in diagnosis, data analysis is a daunting challenge. Here, we present a simple-to-use web service (free for academic use at http://phyresse.org). Delineating both lineage and resistance, it provides state-of-the-art methodology to life scientists and physicians untrained in bioinformatics. It combines elaborate data processing and quality control, as befits human diagnostics, with a treasure trove of validated resistance data collected from well-characterized samples in-house and worldwide.

Indexed as

InternetMycobacterium tuberculosisSoftwareAntitubercular AgentsDrug Resistance, BacterialGenome, BacterialGenomicsHumansTuberculosisAntitubercular Agents

Identifiers

PMID25854485
PMCPMC4432036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.