ArticleInternational journal of molecular sciences2015
In vitro cytotoxic evaluation of MgO nanoparticles and their effect on the expression of ROS genes.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Metal oxide nanoparticles for acne vulgaris: mechanisms, synthesis, formulation, and translational prospects.RSC advances · 2026Review
- Broccoli triggers the hemocompatibility of green nanoparticles.Discover nano · 2026Article
- Ginger phytochemical corona enhances hemocompatibility of metal oxide nanoparticles for blood-contacting applications.Scientific reports · 2026Article
- Magnesium oxide nanoparticles: A novel shield against CCl₄-induced hepatic damage via caspase-3 and TNF-α in rats.Open veterinary journal · 2026Article
- ROS-Sensitive MgOSiOInternational journal of nanomedicine · 2025Article
- Plant-Assisted Green Synthesis of MgO Nanoparticles as a Sustainable Material for Bone Regeneration: Spectroscopic Properties.International journal of molecular sciences · 2024Article
- MgO Nanoparticles Obtained from an Innovative and Sustainable Route and Their Applications in Cancer Therapy.Nanomaterials (Basel, Switzerland) · 2023Article
- Investigation of the Biosafety of Antibacterial Mg(OH)Journal of functional biomaterials · 2023Article
- Antibacterial Properties In Vitro of Magnesium Oxide Nanoparticles for Dental Applications.Nanomaterials (Basel, Switzerland) · 2023Article
- Microenvironmental Behaviour of Nanotheranostic Systems for Controlled Oxidative Stress and Cancer Treatment.Nanomaterials (Basel, Switzerland) · 2022Review
- Radiodynamic therapy with CsI(na)@MgO nanoparticles and 5-aminolevulinic acid.Journal of nanobiotechnology · 2022Article
- Article
- Hypomagnesemia and Its Relationship with Oxidative Stress Markers in Women with Breast Cancer.Biological trace element research · 2021Article
- Biocompatible and Biodegradable Magnesium Oxide Nanoparticles with In Vitro Photostable Near-Infrared Emission: Short-Term Fluorescent Markers.Nanomaterials (Basel, Switzerland) · 2019Article
- Toxicological assessment of magnesium oxide nanoparticles in HT29 intestinal cells.Archives of toxicology · 2019Article
- In vitro evaluation of the toxic effects of MgO nanostructure in Hela cell line.Scientific reports · 2018Article
- A Novel Method to Improve the Anticancer Activity of Natural-Based Hydroxyapatite against the Liver Cancer Cell Line HepG2 Using Mesoporous Magnesia as a Micro-Carrier.Molecules (Basel, Switzerland) · 2017Article
- In vitro evaluation of anticancer and antibacterial activities of cobalt oxide nanoparticles.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Water-dispersible MgO nanoparticles were tested to investigate their cytotoxic effects on oxidative stress gene expression. In this in vitro study, genes related to reactive oxygen species (ROS), glutathione S-transferase (GST) and catalase, were quantified using real-time polymerase chain reactions (molecular level) and molecular beacon technologies (cellular level). The monodispersed MgO nanoparticles, 20 nm in size, were used to treat human cancer cell lines (liver cancer epithelial cells) at different concentrations (25, 75 and 150 µg/mL) and incubation times (24, 48 and 72 h). Both the genetic and cellular cytotoxic screening methods produced consistent results, showing that GST and catalase ROS gene expression was maximized at 150 µg/mL nanoparticle treatment with 48 h incubation. However, the genotoxic effect of MgO nanoparticles was not significant compared with control experiments, which indicates its significant potential applications in nanomedicine as a diagnostic and therapeutic tool.
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