ArticleGenome biology2015
Average genome size estimation improves comparative metagenomics and sheds light on the functional ecology of the human microbiome.
Article in Genome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 224 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
224 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Potential routes of plastics biotransformation involving novel plastizymes revealed by global multi-omic analysis of plastic associated microbes.Scientific reports · 2024Pooled it
- Fecal microbiota transplantation promotes reduction of antimicrobial resistance by strain replacement.Science translational medicine · 2023Trial
- Comparing gut resistome composition among patients with acute Campylobacter infections and healthy family members.Scientific reports · 2021Trial
- Trial
- Meta-CD: a metagenomic sequencing coverage and depth calculator for target species.Microbiology resource announcements · 2026Article
- Functional-Taxonomic Scaling Resolves Conflicting Average Genome Size Estimates Across Environmental Gradients.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Soil Acidification Enriches Antibiotic Resistome.Global change biology · 2026Article
- Sulfur-cycling diazotrophs dominate nitrogen fixation in seagrass sediments.Applied and environmental microbiology · 2026Article
- A Metagenome-Based Methodology to Track Genomically Recoded Strains and Assess Their Effects on Indigenous Microbes.Environmental science & technology · 2026Article
- Genomic characteristics and geographical distribution of uncultivated soil prokaryotes.BMC genomics · 2026Article
- The Prokaryotic Community of Hypersaline Soils from the Odiel Saltmarshes: Culturomics Versus Metagenomics.Life (Basel, Switzerland) · 2026Article
- Tracing NADCell reports · 2026Article
- Impact of ceftiofur administration andmSystems · 2026Article
- Whole metagenome sequencing: not deep enough for complete microbial function recovery.Microbiome · 2026Article
- The soil microbiome of the Caatinga drylands in Brazil.Scientific reports · 2026Article
- Article
- TIPP-SD: A new method for species detection in microbiomes.PLoS computational biology · 2026Article
- Large-scale estimation of bacterial and archaeal DNA prevalence in metagenomes reveals biome-specific patterns.mSystems · 2026Article
- Article
- A previously unappreciated class of metal-dependent bile salt hydrolases from the human gut microbiome.bioRxiv : the preprint server for biology · 2026Article
164 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Average genome size is an important, yet often overlooked, property of microbial communities. We developed MicrobeCensus to rapidly and accurately estimate average genome size from shotgun metagenomic data and applied our tool to 1,352 human microbiome samples. We found that average genome size differs significantly within and between body sites and tracks with major functional and taxonomic differences. In the gut, average genome size is positively correlated with the abundance of Bacteroides and genes related to carbohydrate metabolism. Importantly, we found that average genome size variation can bias comparative analyses, and that normalization improves detection of differentially abundant genes.
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Registered trials
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