Evidence map›Paper›PMID 25853636›Full record

ArticleRadiology2015

Regional Strain Analysis with Multidetector CT in a Swine Cardiomyopathy Model: Relationship to Cardiac MR Tagging and Myocardial Fibrosis.

Michael W Tee, Samuel Won, Fabio S Raman, Colin Yi, Davis M Vigneault, Cynthia Davies-Venn, Songtao Liu, Albert C Lardo, João A C Lima, J Alison Noble and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Advanced myocardial characterization and function with cardiac CT.The international journal of cardiovascular imaging · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Cardiac Computed Tomography - More Than Coronary Arteries? A Clinical Update.RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin · 2019
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Myocardial hypertrophy and its role in heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Michael W TeeFrom the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
Samuel WonFrom the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
Fabio S RamanFrom the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
Colin YiFrom the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
Davis M VigneaultFrom the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
Cynthia Davies-VennFrom the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
Songtao LiuFrom the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
Albert C LardoFrom the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
João A C LimaFrom the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
J Alison NobleFrom the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
Craig A EmterFrom the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
David A BluemkeFrom the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
National Institutes of Health · USJohns Hopkins Medicine · USJohns Hopkins University · USTufts University · USUniversity of Missouri · USUniversity of Oxford · GB

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Molecular Biomedical Imaging Laboratory (NIBIB)ZIAEB000072 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI BLUEMKE, DAVID · 2010 to 2017
$5.0M
Coronary Dysfunction, BK Channels, & Exercise in Heart FailureR01HL112998 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI EMTER, CRAIG ALLEN · 2014 to 2018
$1.8M
Molecular Biomedical Imaging Laboratory (CC)ZIACL090019 · CLC · CLINICAL CENTER · PI JONES, ELIZABETH C. · 2010 to 2017
$0k
CLC NIH HHS CL090019-04Intramural NIH HHSNHLBI NIH HHS R01 HL112998NIBIB NIH HHS EB000072-04NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

purposeTo investigate the use of cine multidetector computed tomography (CT) to detect changes in myocardial function in a swine cardiomyopathy model. MATERIALS AND

methodsAll animal protocols were in accordance with the Principles for the Utilization and Care of Vertebrate Animals Used in Testing Research and Training and approved by the University of Missouri Animal Care and Use Committee. Strain analysis of cine multidetector CT images of the left ventricle was optimized and analyzed with feature-tracking software. The standard of reference for strain was harmonic phase analysis of tagged cardiac magnetic resonance (MR) images at 3.0 T. An animal model of cardiomyopathy was imaged with both cardiac MR and 320-section multidetector CT at a temporal resolution of less than 50 msec. Three groups were evaluated: control group (n = 5), aortic-banded myocardial hypertrophy group (n = 5), and aortic-banded and cyclosporine A- treated cardiomyopathy group (n = 5). Histologic samples of the myocardium were obtained for comparison with strain results. Dunnett test was used for comparisons of the concentric remodeling group and eccentric remodeling group against the control group.

resultsCollagen volume fraction ranged from 10.9% to 14.2%; lower collagen fraction values were seen in the control group than in the cardiomyopathy groups (P < .05). Ejection fraction and conventional metrics showed no significant differences between control and cardiomyopathy groups. Radial strain for both cardiac MR and multidetector CT was abnormal in both concentric (cardiac MR 25.1% ± 4.2; multidetector CT 28.4% ± 2.8) and eccentric (cardiac MR 23.2% ± 2.0; multidetector CT 24.4% ± 2.1) remodeling groups relative to control group (cardiac MR 18.9% ± 1.9, multidetector CT 22.0% ± 1.7, P < .05, all comparisons). Strain values for multidetector CT versus cardiac MR showed better agreement in the radial direction than in the circumferential direction (r = 0.55, P = .03 vs r = 0.40, P = .13, respectively).

conclusionMultidetector CT strain analysis has potential to identify regional wall-motion abnormalities in cardiomyopathy that is not otherwise detected using conventional metrics of myocardial function.

Indexed as

Magnetic Resonance ImagingMultidetector Computed TomographyAnimalsBiomechanical PhenomenaCardiac Imaging TechniquesCardiomyopathiesDisease Models, AnimalFibrosisMaleMyocardiumSwineSwine, Miniature

Identifiers

PMID25853636
PMCPMC4613883
OpenAlexW2097535974

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.