ArticleHeredity2015
Phosphine resistance in India is characterised by a dihydrolipoamide dehydrogenase variant that is otherwise unobserved in eukaryotes.
Article in Heredity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 80 citations in OpenAlex.
- Multiple mutations in Dihydrolipoamide dehydrogenase gene in phosphine resistant Rhyzopertha Dominica populations from India.Molecular biology reports · 2025Article
- Article
- Transcriptome profiling and in silico docking analysis of phosphine resistance in rice weevil, Sitophilus oryzae (Coleoptera: Curculionidae).Journal of insect science (Online) · 2023Article
- Comparison of phenotypic and genotypic frequency of phosphine resistance in select field populations of Tribolium castaneum from India.Molecular biology reports · 2023Article
- Article
- Differential Activities of Antioxidant Enzymes, Superoxide Dismutase, Peroxidase, and Catalase vis-à-vis Phosphine Resistance in Field Populations of Lesser Grain Borer (Antioxidants (Basel, Switzerland) · 2023Article
- Detection of Phosphine Resistance in Field Populations of Four Key Stored-Grain Insect Pests in Pakistan.Insects · 2021Article
- Delayed mortality, resistance and the sweet spot, as the good, the bad and the ugly in phosphine use.Scientific reports · 2021Article
- Fumigation Activity against Phosphine-ResistantInsects · 2020Article
- Response of Suidasia pontifica (Acaridida: Suidasiidae) to phosphine fumigation.Experimental & applied acarology · 2019Article
- Minimization of energy transduction confers resistance to phosphine in the rice weevil, Sitophilus oryzae.Scientific reports · 2019Article
- Reference gene selection to determine differences in mitochondrial gene expressions in phosphine-susceptible and phosphine-resistant strains of Cryptolestes ferrugineus, using qRT-PCR.Scientific reports · 2017Article
- Genetic Conservation of Phosphine Resistance in the Rice Weevil Sitophilus oryzae (L.).The Journal of heredity · 2016Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphine (PH3) fumigation is the primary method worldwide for controlling insect pests of stored commodities. Over-reliance on phosphine, however, has led to the emergence of strong resistance. Detailed genetic studies previously identified two loci, rph1 and rph2, that interact synergistically to create a strong resistance phenotype. We compared the genetics of phosphine resistance in strains of Rhyzopertha dominica and Tribolium castaneum from India and Australia, countries having similar pest species but widely differing in pest management practices. Sequencing analysis of the rph2 locus, dihydrolipoamide dehydrogenase (dld), identified two structurally equivalent variants, Proline49>Serine (P49S) in one R. dominica strain and P45S in three strains of T. castaneum from India. These variants of the DLD protein likely affect FAD cofactor interaction with the enzyme. A survey of insects from storage facilities across southern India revealed that the P45/49S variant is distributed throughout the region at very high frequencies, in up to 94% of R. dominica and 97% of T. castaneum in the state of Tamil Nadu. The abundance of the P45/49S variant in insect populations contrasted sharply with the evolutionary record in which the variant was absent from eukaryotic DLD sequences. This suggests that the variant is unlikely to provide a strong selective advantage in the absence of phosphine fumigation.
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