SynthesisPLoS computational biology2015
A Bayesian model of category-specific emotional brain responses.
Synthesis in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
115 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- A working model linking the psychopathology and pathophysiology of major depressive disorder - an umbrella review of neuroimaging studies and a conceptual framework.Molecular psychiatry · 2025Pooled it
- Meta-analytic activation maps can help identify affective processes captured by contrast-based task fMRI: the case of threat-related facial expressions.Social cognitive and affective neuroscience · 2022Pooled it
- Separate neural networks of implicit emotional processing between pictures and words: A coordinate-based meta-analysis of brain imaging studies.Neuroscience and biobehavioral reviews · 2021Pooled it
- Large-scale Meta-analysis Suggests Low Regional Modularity in Lateral Frontal Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2018Pooled it
- Dissociable meta-analytic brain networks contribute to coordinated emotional processing.Human brain mapping · 2018Pooled it
- Emotion fingerprints or emotion populations? A meta-analytic investigation of autonomic features of emotion categories.Psychological bulletin · 2018Pooled it
- Frontal-Brainstem Pathways Mediating Placebo Effects on Social Rejection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Trial
- Intrinsic network static and dynamic functional connectivity associated with induced affect.Social cognitive and affective neuroscience · 2026Article
- Loneliness exacerbates age differences in the -allostatic-interoceptive system during induced affect.Social cognitive and affective neuroscience · 2026Article
- Spatiotemporal dynamics of multispectral oscillatory activity underlying the processing of negative and positive emotional images.NeuroImage · 2025Article
- Distinct neural computations scale the violation of expected reward and emotion in social transgressions.Communications biology · 2025Article
- Acculturative stress, loneliness, smartphone addiction, L2 emotions, and creativity among international students in China: a structural equation model.Frontiers in psychiatry · 2025Article
- Statistical learning across cognitive and affective domains: a multidimensional review.Frontiers in integrative neuroscience · 2025Review
- Modeling the arousal potential of epistemic emotions using Bayesian information gain: a framework for inquiry cycles driven by free energy fluctuations.Frontiers in psychology · 2025Article
- Imaging joy with generalized slice dithered enhanced resolution and SWAT reconstruction: 3T high spatial-temporal resolution fMRI.Frontiers in neuroimaging · 2025Article
- Functional brain connectivity changes associated with day-to-day fluctuations in affective states.Cognitive, affective & behavioral neuroscience · 2024Article
- More than labels: neural representations of emotion words are widely distributed across the brain.Social cognitive and affective neuroscience · 2024Article
- Occipital-temporal cortical tuning to semantic and affective features of natural images predicts associated behavioral responses.Nature communications · 2024Article
- A neurofunctional signature of subjective disgust generalizes to oral distaste and socio-moral contexts.Nature human behaviour · 2024Article
- Cortico-cortical transfer of socially derived information gates emotion recognition.Nature neuroscience · 2024Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Understanding emotion is critical for a science of healthy and disordered brain function, but the neurophysiological basis of emotional experience is still poorly understood. We analyzed human brain activity patterns from 148 studies of emotion categories (2159 total participants) using a novel hierarchical Bayesian model. The model allowed us to classify which of five categories--fear, anger, disgust, sadness, or happiness--is engaged by a study with 66% accuracy (43-86% across categories). Analyses of the activity patterns encoded in the model revealed that each emotion category is associated with unique, prototypical patterns of activity across multiple brain systems including the cortex, thalamus, amygdala, and other structures. The results indicate that emotion categories are not contained within any one region or system, but are represented as configurations across multiple brain networks. The model provides a precise summary of the prototypical patterns for each emotion category, and demonstrates that a sufficient characterization of emotion categories relies on (a) differential patterns of involvement in neocortical systems that differ between humans and other species, and (b) distinctive patterns of cortical-subcortical interactions. Thus, these findings are incompatible with several contemporary theories of emotion, including those that emphasize emotion-dedicated brain systems and those that propose emotion is localized primarily in subcortical activity. They are consistent with componential and constructionist views, which propose that emotions are differentiated by a combination of perceptual, mnemonic, prospective, and motivational elements. Such brain-based models of emotion provide a foundation for new translational and clinical approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.