ArticleGenome biology2015
Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming.
Article in Genome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 136 citations in OpenAlex.
- DNA Methylation: A Key Regulator in Male and Female Reproductive Outcomes.Life (Basel, Switzerland) · 2025Review
- The Effect of Bisphenol and Its Cytotoxicity on Female Infertility and Pregnancy Outcomes: A Narrative Review.Journal of clinical medicine · 2024Review
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- Impact of Bisphenol A and its alternatives on oocyte health: a scoping review.Human reproduction update · 2024Article
- Unaltered hepatic wound healing response in male rats with ancestral liver injury.Nature communications · 2023Article
- Establishment of paternal methylation imprint at theScience advances · 2023Article
- Preterm Birth, Developmental Smoke/Nicotine Exposure, and Life-Long Pulmonary Sequelae.Children (Basel, Switzerland) · 2023Review
- Review
- Impact ofFrontiers in toxicology · 2022Article
- Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure.Environmental health perspectives · 2021Article
- Simulated Wildfire Smoke Significantly Alters Sperm DNA Methylation Patterns in a Murine Model.Toxics · 2021Article
- Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate.eLife · 2021Article
- Review
- Associations of parental birth characteristics with autism spectrum disorder (ASD) risk in their offspring: a population-based multigenerational cohort study in Denmark.International journal of epidemiology · 2021Article
- Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes.Cell reports · 2021Article
- Epigenetic Transgenerational Inheritance of the Effects of Obesogen Exposure.Frontiers in endocrinology · 2021Review
- Single-cell transcriptome dissection of the toxic impact of Di (2-ethylhexyl) phthalate on primordial follicle assembly.Theranostics · 2021Article
- Maternal DOT1L is dispensable for mouse development.Scientific reports · 2020Article
- The social construction of the social epigenome and the larger biological context.Epigenetics & chromatin · 2020Review
- Perinatal nicotine exposure-induced transgenerational asthma: Effects of reexposure in F1 gestation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundExposure to environmental endocrine-disrupting chemicals during pregnancy reportedly causes transgenerationally inherited reproductive defects. We hypothesized that to affect the grandchild, endocrine-disrupting chemicals must alter the epigenome of the germ cells of the in utero-exposed G1 male fetus. Additionally, to affect the great-grandchild, the aberration must persist in the germ cells of the unexposed G2 grandchild.
resultsHere, we treat gestating female mice with vinclozolin, bisphenol A, or di-(2-ethylhexyl)phthalate during the time when global de novo DNA methylation and imprint establishment occurs in the germ cells of the G1 male fetus. We map genome-wide features in purified G1 and G2 prospermatogonia, in order to detect immediate and persistent epigenetic aberrations, respectively. We detect changes in transcription and methylation in the G1 germline immediately after endocrine-disrupting chemicals exposure, but changes do not persist into the G2 germline. Additional analysis of genomic imprints shows no persistent aberrations in DNA methylation at the differentially methylated regions of imprinted genes between the G1 and G2 prospermatogonia, or in the allele-specific transcription of imprinted genes between the G2 and G3 soma.
conclusionsOur results suggest that endocrine-disrupting chemicals exert direct epigenetic effects in exposed fetal germ cells, which are corrected by reprogramming events in the next generation. Avoiding transgenerational inheritance of environmentally-caused epigenetic aberrations may have played an evolutionary role in the development of dual waves of global epigenome reprogramming in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.