Trial reportJournal of clinical psychopharmacology2015
Effects of acute doses of prosocial drugs methamphetamine and alcohol on plasma oxytocin levels.
Trial report in Journal of clinical psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Alcohol does not influence trust in others or oxytocin, but increases positive affect and risk-taking: a randomized, controlled, within-subject trial.European archives of psychiatry and clinical neuroscience · 2024Trial
- Effects of MDMA on attention to positive social cues and pleasantness of affective touch.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- Acute effects of lisdexamfetamine and D-amphetamine on social cognition and cognitive performance in a placebo-controlled study in healthy subjects.Psychopharmacology · 2018Trial
- Alcohol acutely enhances decoding of positive emotions and emotional concern for positive stimuli and facilitates the viewing of sexual images.Psychopharmacology · 2017Trial
- MDMA as well as amphetamine and alcohol increase feelings of social closeness in healthy adults.Scientific reports · 2024Article
- Drug-induced social connection: both MDMA and methamphetamine increase feelings of connectedness during controlled dyadic conversations.Scientific reports · 2023Article
- Beta-Endorphin and Oxytocin in Patients with Alcohol Use Disorder and Comorbid Depression.Journal of clinical medicine · 2021Article
- Alcohol and oxytocin: Scrutinizing the relationship.Neuroscience and biobehavioral reviews · 2021Review
- A prior history of binge-drinking increases sensitivity to the motivational valence of methamphetamine in female C57BL/6J mice.Substance abuse : research and treatment · 2020Article
- Considering the context: social factors in responses to drugs in humans.Psychopharmacology · 2018Review
- Prior binge-drinking history promotes the positive affective valence of methamphetamine in mice.Drug and alcohol dependence · 2018Article
- Effect of alcohol use disorder on oxytocin peptide and receptor mRNA expression in human brain: A post-mortem case-control study.Psychoneuroendocrinology · 2017Article
- Methamphetamine-alcohol interactions in murine models of sequential and simultaneous oral drug-taking.Drug and alcohol dependence · 2017Article
- A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence.Psychopharmacology · 2017Article
- The effects of MDMA on socio-emotional processing: Does MDMA differ from other stimulants?Journal of psychopharmacology (Oxford, England) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Many drugs, including alcohol and stimulants, demonstrably increase sociability and verbal interaction and are recreationally consumed in social settings. One drug, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), seems to produce its prosocial effects by increasing plasma oxytocin levels, and the oxytocin system has been implicated in responses to several other drugs of abuse. Here, we sought to investigate the effects of 2 other "social" drugs on plasma oxytocin levels--methamphetamine and alcohol. Based on their shared capacity to enhance sociability, we hypothesized that both methamphetamine and alcohol would increase plasma oxytocin levels. In study 1, 11 healthy adult volunteers attended 3 sessions during which they received methamphetamine (10 mg or 20 mg) or placebo under double-blind conditions. Subjective drug effects, cardiovascular effects, and plasma oxytocin levels were measured at regular intervals throughout the sessions. In study 2, 8 healthy adult volunteers attended a single session during which they received 1 beverage containing placebo, and then a beverage containing alcohol (0.8 g/kg). Subjective effects, breath alcohol levels, and plasma oxytocin levels were measured at regular intervals. Both methamphetamine and alcohol produced their expected physiological and subjective effects, but neither of these drugs increased plasma oxytocin levels. The neurobiological mechanisms mediating the prosocial effects of drugs such as alcohol and methamphetamine remain to be identified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.