Evidence map›Paper›PMID 25853146›Full record

ReviewTheScientificWorldJournal2015

Fibrin gel as an injectable biodegradable scaffold and cell carrier for tissue engineering.

Yuting Li, Hao Meng, Yuan Liu, Bruce P Lee

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in TheScientificWorldJournal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Human stem cells with in vivo high plasticity generated by cell-cell communication.Proceedings of the National Academy of Sciences of the United States of America · 2025
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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuting LiDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.
Hao MengDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.
Yuan LiuDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.
Bruce P LeeDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.ORCID 0000-0002-6529-0032

Funding

Biomimetic Tissue Adhesive with Mechanically Tough Hydrogel SupportR15GM104846 · NIGMS · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI LEE, BRUCE P · 2013 to 2016
$757k
6 · The paper itself

Abstract

Due to the increasing needs for organ transplantation and a universal shortage of donated tissues, tissue engineering emerges as a useful approach to engineer functional tissues. Although different synthetic materials have been used to fabricate tissue engineering scaffolds, they have many limitations such as the biocompatibility concerns, the inability to support cell attachment, and undesirable degradation rate. Fibrin gel, a biopolymeric material, provides numerous advantages over synthetic materials in functioning as a tissue engineering scaffold and a cell carrier. Fibrin gel exhibits excellent biocompatibility, promotes cell attachment, and can degrade in a controllable manner. Additionally, fibrin gel mimics the natural blood-clotting process and self-assembles into a polymer network. The ability for fibrin to cure in situ has been exploited to develop injectable scaffolds for the repair of damaged cardiac and cartilage tissues. Additionally, fibrin gel has been utilized as a cell carrier to protect cells from the forces during the application and cell delivery processes while enhancing the cell viability and tissue regeneration. Here, we review the recent advancement in developing fibrin-based biomaterials for the development of injectable tissue engineering scaffold and cell carriers.

Indexed as

Biocompatible MaterialsTissue EngineeringTissue ScaffoldsFibrinGelsHumansBiocompatible MaterialsFibrinGels

Identifiers

PMID25853146
PMCPMC4380102

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.